Dr Simon Archer

Reader in Chronobiology, Biochemistry Admissions Tutor, Sleep Chronobiology and Neurodisorders Theme Leader

Qualifications: BSc, PhD

Email:
Phone: Work: 01483 68 6408
Room no: 03 AY 02

Office hours

By appoinment

Further information

Biography

Dr Archer received his BSc in Biological Sciences from the University of Sussex and his PhD in Zoology from the University of Bristol, where he studied photoreceptor visual pigment absorbance spectra and colour vision polymorphisms. As a postdoctoral fellow at Bristol, he cloned some of the first visual pigment opsin genes, before moving to Sardinia on a EU Fellowship to help to set up the International Marine Centre (IMC) at Oristano, where he was Group Leader of Molecular Sensory Ecology. He then joined chronobiology researchers at Surrey, where he is now a Reader in Chronobiology. His current research interests include the molecular aspects of the circadian clock and sleep homeostat systems. He is particularly interested in how polymorphisms in sleep and circadian genes can affect gene expression and function, and be associated with inter-individual differences in sleep and circadian-related phenotypes, in both humans and animal models.

Dr Archer has published over 45 peer-reviewed papers and invited reviews, and edited two books. He is a member of the British Sleep Society, the European Sleep Research Society, and the Society for Research on Biological Rhythms.

Research Interests

 

  • Human sleep and circadian genetics
  • Human sleep and circadian genotype-phenotype associations
  • Transgenic sleep and circadian models
  • Circadian clock gene expression

Current Research Funding

BBSRC New Investigator Award (2007-2010) 'Genetic and phenotypic outputs of the circadian clock in Per3 knock-out and humanised Per3 knock-in mice. S N Archer (PI)

BBSRC (2008-2011). 'Circadian and homeostatic contributions to physiology, cognition and genome-wide expression in human and mouse variants of the PER3 VNTR polymorphism'. D-J Dijk (PI), J Groeger, S N Archer, M von Schantz, C P Smith, & J Johnston

AFOSR (2008-2011). 'Cognitive vulnerability following extended wakefullness in defined genotypes''. D-J Dijk (PI), J Groeger, S N Archer, M von Schantz, C P Smith & A Kierzek

Philips Lighting (2009-2010) Evaluation of evening light regimes which minimise suppression of melatonin and the nocturnal increase in sleepiness but maintain visual function, D-J Dijk (PI) & S N Archer, £144,593

Publications

Highlights

  • Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010) 'Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (5), pp. 695-701.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk DJ. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE J NEUROSCI, 29 (25), pp. 7948-7956.
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk DJ. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.
  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk DJ. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURR BIOL, 17 (7), pp. 613-618.

Journal articles

  • Viola AU, Chellappa SL, Archer SN, Pugin F, Götz T, Dijk DJ, Cajochen C. (2011) 'Interindividual differences in circadian rhythmicity and sleep homeostasis in older people: effect of a PER3 polymorphism.'. Neurobiol Aging, United States: 33 (5), pp. 1010.e17-1010.e27.
  • Hasan S, van der Veen DR, Winsky-Sommerer R, Dijk DJ, Archer SN. (2011) 'Altered sleep and behavioral activity phenotypes in PER3-deficient mice.'. Am J Physiol Regul Integr Comp Physiol, United States: 301 (6), pp. R1821-R1830.
  • Santhi N, Thorne HC, van der Veen DR, Johnsen S, Mills SL, Hommes V, Schlangen LJ, Archer SN, Dijk DJ. (2011) 'The spectral composition of evening light and individual differences in the suppression of melatonin and delay of sleep in humans.'. J Pineal Res,
  • Barclay NL, Eley TC, Mill J, Wong CCY, Zavos HMS, Archer SN, Gregory AM. (2011) 'Sleep Quality and Diurnal Preference in a Sample of Young Adults: Associations With 5HTTLPR, PER3, and CLOCK 3111'. WILEY-BLACKWELL AM J MED GENET B, 156B (6), pp. 681-690.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk DJ, Maquet P. (2011) 'Effects of light on cognitive brain responses depend on circadian phase and sleep homeostasis.'. J Biol Rhythms, United States: 26 (3), pp. 249-259.
  • Dijk DJ, Archer SN. (2010) 'PERIOD3, circadian phenotypes, and sleep homeostasis'. W B SAUNDERS CO LTD SLEEP MED REV, 14 (3), pp. 151-160.
  • Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010) 'Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (5), pp. 695-701.
  • van der Veen DR, Archer SN. (2010) 'Light-Dependent Behavioral Phenotypes in PER3-Deficient Mice'. SAGE PUBLICATIONS INC J BIOL RHYTHM, 25 (1), pp. 3-8.
  • Barclay NL, Eley TC, Buysse DJ, Archer SN, Gregory AM. (2010) 'DIURNAL PREFERENCE AND SLEEP QUALITY: SAME GENES? A STUDY OF YOUNG ADULT TWINS'. TAYLOR & FRANCIS INC CHRONOBIOL INT, 27 (2), pp. 278-296.
  • Van der Veen DR, Archer SN. (2010) 'Light-dependent behavioral phenotypes in PER3-deficient mice (vol 25, pg 3, 2010)'. SAGE PUBLICATIONS INC J BIOL RHYTHM, 25 (2), pp. 150-150.
  • Staples VSL, Archer SN, Arber S, Skene DJ. (2009) 'Daily light exposure profiles in older non-resident extreme morning and evening types'. WILEY-BLACKWELL PUBLISHING, INC J SLEEP RES, 18 (4), pp. 466-471.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk DJ. (2009) 'Functional Magnetic Resonance Imaging-Assessed Brain Responses during an Executive Task Depend on Interaction of Sleep Homeostasis, Circadian Phase, and PER3 Genotype'. SOC NEUROSCIENCE J NEUROSCI, 29 (25), pp. 7948-7956.
  • Dijk DJ, Archer SN. (2009) 'Light, Sleep, and Circadian Rhythms: Together Again'. PUBLIC LIBRARY SCIENCE PLOS BIOL, 7 (6) Article number e1000145
  • Skene DJ, Sletten TL, Ackermann K, Herljevic M, Lederle KA, Middleton B, Archer SN, Revell VL. (2009) 'LIGHT AND THE HUMAN CIRCADIAN TIMING SYSTEM: AGE-RELATED CHANGES'. SPRINGER TOKYO J PHYSIOL SCI, 59, pp. 37-37.
  • Pugin F, Viola AU, Chellappa SL, Archer S, Dijk DJ, Cajochen C. (2009) 'Can Per3 Length Polymorphism Predict Sleep Duration in Older Individuals?'. KARGER NEUROPSYCHOBIOLOGY, 59 (4), pp. 255-255.
  • Dijk D-J, Archer SN. (2009) 'Circadian and Homeostatic Regulation of Human Sleep and Cognitive Performance and Its Modulation by PERIOD3'. Sleep Medicine Clinics, 4 (2), pp. 111-125.
  • Ellis J, von Schantz M, Jones KHS, Archer SN. (2009) 'Association between Specific Diurnal Preference Questionnaire Items and PER3 VNTR Genotype'. TAYLOR & FRANCIS INC CHRONOBIOL INT, 26 (3), pp. 464-473.
  • Thorne HC, Jones KH, Peters SP, Archer SN, Dijk DJ. (2009) 'Daily and Seasonal Variation in the Spectral Composition of Light Exposure in Humans'. TAYLOR & FRANCIS INC CHRONOBIOL INT, 26 (5), pp. 854-866.
  • Ackermann K, Sletten TL, Revell VL, Archer SN, Skene DJ. (2009) 'Blue-Light Phase Shifts PER3 Gene Expression in Human Leukocytes'. TAYLOR & FRANCIS INC CHRONOBIOL INT, 26 (4), pp. 769-779.
  • Viola AU, James LM, Archer SN, Dijk DJ. (2008) 'PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase'. AMER PHYSIOLOGICAL SOC AM J PHYSIOL-HEART C, 295 (5), pp. H2156-H2163.
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk DJ. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.
  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk DJ. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURR BIOL, 17 (7), pp. 613-618.
  • Jones KHS, Ellis J, Von Schantz M, Skene DJ, Dijk DJ, Archer SN. (2007) 'Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING J SLEEP RES, 16 (1), pp. 12-16.
  • Hogben AL, Ellis J, Archer SN, Von Schantz M. (2007) 'Conscientiousness is a predictor of diurnal preference'. Chronobiology International, 24 (6), pp. 1249-1254.
  • Hogben AL, Ellis J, Archer SN, von Schantz M. (2007) 'Conscientiousness is a predictor of diurnal preference.'. Chronobiol Int, United States: 24 (6), pp. 1249-1254.
  • von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. SPRINGER J MOL EVOL, 62 (6), pp. 701-707.
  • Von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. Journal of Molecular Evolution, 62 (6), pp. 701-707.
  • Carpen JD, von Schantz M, Smits M, Skene DJ, Archer SN. (2006) 'A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans'. SPRINGER TOKYO J HUM GENET, 51 (12), pp. 1122-1125.
  • Jenkins A, Archer SN, von Schantz M. (2005) 'Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene Period3'. SAGE PUBLICATIONS LTD J BIOL RHYTHM, 20 (5), pp. 470-472.
  • Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M. (2005) 'A single-nucleotide polymorphism in the 5 '-untranslated region of the hPER2 gene is associated with diurnal preference'. BLACKWELL PUBLISHING J SLEEP RES, 14 (3), pp. 293-297.
  • Carpen JD, Archer SN, Skene DJ, Smits M, Von Schantz M. (2005) 'A single-nucleotide polymorphism in the 5′-untranslated region of the hPER2 gene is associated with diurnal preference'. Journal of Sleep Research, 14 (3), pp. 293-297.
  • Van Der Heijden KB, Blok MJ, Spee K, Archer SN, Smits MG, Curfs LM, Gunning WB. (2005) 'No evidence to support an association of PER3 clock gene polymorphism with ADHD-related idiopathic chronic sleep onset insomnia'. Biological Rhythm Research, 36 (5), pp. 381-388.
  • Jenkins A, Archer SN, Von Schantz M. (2005) 'Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene Period3'. Journal of Biological Rhythms, 20 (5), pp. 470-472.
  • Archer SN, Ahuja P, Caffe R, Mikol C, Foster RG, van Veen T, von Schantz M. (2004) 'Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells'. BLACKWELL PUBLISHING LTD EUR J NEUROSCI, 19 (11), pp. 2923-2930.
  • von Schantz M, Archer SN. (2003) 'Clocks, genes and sleep'. ROYAL SOC MEDICINE PRESS LTD J ROY SOC MED, 96 (10), pp. 486-489.
  • Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. AMER ACAD SLEEP MEDICINE SLEEP, 26 (4), pp. 413-415.
  • Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, Von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. Sleep, 26 (4), pp. 413-415.
  • Von Schantz M, Archer SN. (2003) 'Clocks, genes and sleep'. Journal of the Royal Society of Medicine, 96 (10), pp. 486-489.
  • Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, von Schantz M. (2002) 'The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects'. BLACKWELL PUBLISHING LTD J SLEEP RES, 11 (4), pp. 305-312.
  • Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, Von Schantz M. (2002) 'The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects'. Journal of Sleep Research, 11 (4), pp. 305-312.
  • Archer S, Hope A, Partridge JC. (1995) 'The molecular basis for the green-blue sensitivity shift in the rod visual pigments of the European eel'. ROYAL SOC LONDON P ROY SOC LOND B BIO, 262 (1365), pp. 289-295.
  • ARCHER SN, LYTHGOE JN, HALL L. (1992) 'ROD OPSIN CDNA SEQUENCE FROM THE SAND GOBY (POMATOSCHISTUS-MINUTUS) COMPARED WITH THOSE OF OTHER VERTEBRATES'. ROYAL SOC LONDON P ROY SOC LOND B BIO, 248 (1321), pp. 19-25.
  • PARTRIDGE JC, ARCHER SN, VANOOSTRUM J. (1992) 'SINGLE AND MULTIPLE VISUAL PIGMENTS IN DEEP-SEA FISHES'. CAMBRIDGE UNIV PRESS J MAR BIOL ASSOC UK, 72 (1), pp. 113-130.
  • ARCHER SN, LYTHGOE JN. (1990) 'THE VISUAL PIGMENT BASIS FOR CONE POLYMORPHISM IN THE GUPPY, POECILIA-RETICULATA'. PERGAMON-ELSEVIER SCIENCE LTD VISION RES, 30 (2), pp. 225-233.
  • Partridge JC, Shand J, Archer SN, Lythgoe JN, van Groningen-Luyben WAHM. (1989) 'Interspecific variation in the visual pigments of deep-sea fishes'. Journal of Comparative Physiology A, 164 (4), pp. 513-529.
  • ARCHER SN, ENDLER JA, LYTHGOE JN, PARTRIDGE JC. (1987) 'VISUAL PIGMENT POLYMORPHISM IN THE GUPPY POECILIA-RETICULATA'. PERGAMON-ELSEVIER SCIENCE LTD VISION RES, 27 (8), pp. 1243-1252.

Conference papers

  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Dijk D, Maquet P. (2009) 'MODULATION OF FMRI ASSESSED BRAIN RESPONSES TO BLUE AND GREEN LIGHT BY SLEEP HOMFOSTASIS, CIRCADIAN PHASE AND PER3 POLYMORPHISM'. AMER ACAD SLEEP MEDICINE SLEEP, Seattle, WA: 23rd Annual Meeting of the Associated-Professional-Sleep-Scoieties 32, pp. A1-A1.
  • Vaughan V, Archer S, Skene DJ, Arber S. (2008) 'Daily light exposure profiles in older extreme morning and evening types'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 73-73.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 1-1.
  • Vandewalle G, Archer S, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'Polymorphism in period3 predicts fMRI-assessed inter-individual differences in the effects of sleep deprivation'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • Groeger JA, Lo JC, Viola AU, Schantz MV, Archer SN, Dijk D. (2008) 'Period3 and the effects of sleep deprivation on executive function: the importance of circadian phase'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 38-38.
  • Von Schantz W, Carpen JD, Gibson M, Lim G, Johnston J, Skene DJ, Archer SN. (2008) 'Analysis of the PER3 promoter and haplotypes that associate with diurnal preference and delayed sleep phase disorder'. WILEY-BLACKWELL PUBLISHING, INC JOURNAL OF SLEEP RESEARCH, Glasgow, SCOTLAND: 19th Congress of the European-Sleep-Research-Society 17, pp. 80-80.
  • James LM, Viola AU, Archer SN, Dijk D. (2008) 'Topography of the effects of a PER3 polymorphism on alpha activity in REM sleep under baseline and recovery conditions'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A107-A107.
  • Vandewalle G, Archer SN, Wuillaume C, Balteau E, Degueldre C, Luxen A, Maquet P, Dijk D. (2008) 'A period 3 polymorphism predicts FMRI assessed brain responses following sleep loss'. AMER ACAD SLEEP MEDICINE SLEEP, Baltimore, MD: 22nd Annual Meeting of the Associated-Professional-Sleep-Societies 31, pp. A111-A111.
  • Groeger J, Lo J, Viola A, Von Schantz M, Archer S, Dijk D. (2007) 'PER3 polymorphism predictssusceptibility to sleep deprivation-induced impairment of early morning executive performance'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A54.
  • Archer S, Viola A, Von Schantz M, Dijk D. (2007) 'Endogenous circadian rhythm of PER3 RNA in human leucocytes: Association with sleep timing, melatonin rhythm, and PER3 genotype'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A55.
  • Jones KH, Ellis J, Von Schantz M, Skene DJ, Dijk D, Archer SN. (2006) 'Age-related change in the association between a variable number tandem repeat polymorphism in the (PER3) gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 97-98.
  • Viola AU, Archer SN, Groeger JA, Skene DJ, Von Schantz M, Dijk DJ. (2006) 'Polymorphism in the clock gene PER3 predicts sleep structure and EEG power spectra'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 53-53.
  • Vaughan V, Meadows R, Archer SN, Skene DJ, Arber S. (2006) 'Diurnal preference in couples: negotiating sleep timing'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 95-95.
  • Von Schantz M, Archer SN. (2006) 'Genetic aspects of delayed sleep phase syndrome (DSPS)'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 5-5.
  • Archer SN, Robillard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A109-A109.
  • Archer SN, Lucas RJ, Thompson S, Foster RG, von Schantz M. (2002) 'Identification of a novel retinal kinase with promoter elements affected by circadian clock proteins'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, FT LAUDERDALE, FLORIDA: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology 43, pp. U308-U308.

Teaching

 

BMS1007 - Practical Cell & Molecular Biology (Module coordinator)

BMS2023 - Analytical Biochemistry

BMS3034 - Biological Rhythms

BMS3042 - Neuroscience: From Molecules to Mind

MSc Clinical Biochemistry

Departmental Duties

 

Biochemistry Admissions Tutor

Sleep, Chronobiology & Neurodisorders Theme Leader

Affiliations

 

British Sleep Society - member

European Sleep Research Society - member

Society for Research on Biological Rhythms - member