Dr Malcolm von Schantz

Reader in Molecular Neurobiology

Qualifications: BSc MSc PhD FLS

Email:
Phone: Work: 01483 68 6468
Room no: 08 AY 02

Further information

Biography

Employment

  • Reader in Molecular Neurobiology, University of Surrey, since 2009
  • Senior Lecturer in Physiology and Biochemistry, University of Surrey
  • Lecturer in Physiology and Biochemistry, University of Surrey
  • Postdoctoral Fellow, Imperial College

Education

  • PhD, Gothenburg University
  • MSc, Lund University
  • BSc, Lund University

Research Interests

  • Circadian rhythms
  • Clock genes
  • Molecular evolution
  • Sleep

Current research funding

  • BBSRC
  • United States Air Force Office of Scientific Research
  • Royal Society
  • Daiwa Foundation

Publications

Journal articles

  • Archer SN, Laing EE, Möller-Levet CS, van der Veen DR, Bucca G, Lazar AS, Santhi N, Slak A, Kabiljo R, von Schantz M, Smith CP, Dijk DJ. (2014) 'Mistimed sleep disrupts circadian regulation of the human transcriptome.'. Proc Natl Acad Sci U S A,
  • Möller-Levet CS, Archer SN, Bucca G, Laing EE, Slak A, Kabiljo R, Lo JC, Santhi N, von Schantz M, Smith CP, Dijk DJ. (2013) 'Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.'. Proc Natl Acad Sci U S A, United States: 110 (12), pp. E1132-E1141.
  • Lazar AS, Santhi N, Hasan S, Lo JC, Johnston JD, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Circadian period and the timing of melatonin onset in men and women: predictors of sleep during the weekend and in the laboratory.'. J Sleep Res,
  • Lázár AS, Slak A, Lo JC, Santhi N, von Schantz M, Archer SN, Groeger JA, Dijk DJ. (2012) 'Sleep, diurnal preference, health, and psychological well-being: a prospective single-allelic-variation study.'. Chronobiol Int, England: 29 (2), pp. 131-146.
  • Hasan S, Santhi N, Lazar AS, Slak A, Lo J, von Schantz M, Archer SN, Johnston JD, Dijk DJ. (2012) 'Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin.'. FASEB J,
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of partial and acute total sleep deprivation on performance across cognitive domains, individuals and circadian phase.'. PLoS One, United States: 7 (9)

    Abstract

    Cognitive performance deteriorates during extended wakefulness and circadian phase misalignment, and some individuals are more affected than others. Whether performance is affected similarly across cognitive domains, or whether cognitive processes involving Executive Functions are more sensitive to sleep and circadian misalignment than Alertness and Sustained Attention, is a matter of debate.

  • Archer SN, Carpen JD, Gibson M, Lim GH, Johnston JD, Skene DJ, von Schantz M. (2010) 'Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder'. AMER ACAD SLEEP MEDICINE SLEEP, 33 (5), pp. 695-701.

    Abstract

    Study Objectives: To screen the PER3 promoter for polymorphisms and investigate the phenotypic associations of these polymorphisms with diurnal preference, delayed sleep phase disorder/syndrome (DSPD/DSPS), and their effects on reporter gene expression. Design: Interspecific comparison was used to define the approximate extent of the PER3 promoter as the region between the transcriptional start site and nucleotide position −874. This region was screened in DNA pools using PCR and direct sequencing, which was also used to screen DNA from individual participants. The different promoter alleles were cloned into a luciferase expression vector and a deletion library created. Promoter activation was measured by chemiluminescence. Setting: N/A Patients or Participants: DNA samples were obtained from volunteers with defined diurnal preference (3 x 80, selected from a pool of 1,590), and DSPD patients (n = 23). Interventions: N/A Measurements and Results: We verified three single nucleotide polymorphisms (G −320T, C −319A, G −294A), and found a novel variable number tandem repeat (VNTR) polymorphism (−318 1/2 VNTR). The −320T and −319A alleles occurred more frequently in DSPD compared to morning (P = 0.042 for each) or evening types (P = 0.006 and 0.033). The allele combination TA2G was more prevalent in DSPD compared to morning (P = 0.033) or evening types (P = 0.002). Luciferase expression driven by the TA2G combination was greater than for the more common GC2A (P < 0.05) and the rarer TA1G (P < 0.001) combinations. Deletion reporter constructs identified two enhancer regions (−703 to −605, and −283 to −80). Conclusions: Polymorphisms in the PER3 promoter could affect its expression, leading to potential differences in the observed functions of PER3.

  • Ellis J, von Schantz M, Jones KHS, Archer SN. (2009) 'Association between Specific Diurnal Preference Questionnaire Items and PER3 VNTR Genotype'. TAYLOR & FRANCIS INC CHRONOBIOLOGY INTERNATIONAL, 26 (3) Article number PII 910356950 , pp. 464-473.
  • Von Schantz M. (2008) 'Phenotypic effects of genetic variability in human clock genes on circadian and sleep parameters'. INDIAN ACAD SCIENCES JOURNAL OF GENETICS, 87 (5), pp. 513-519.
  • Groeger JA, Viola AU, Lo JCY, von Schantz M, Archer SN, Dijk D-J. (2008) 'Early morning executive functioning during sleep deprivation is compromised by a PERIOD3 polymorphism'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (8), pp. 1159-1167.
  • Archer SN, Viola AU, Kyriakopoulou V, von Schantz M, Dijk DJ. (2008) 'Inter-individual differences in habitual sleep timing and entrained phase of endogenous circadian rhythms of BMAL1, PER2 and PER3 mRNA in human leukocytes'. AMER ACAD SLEEP MEDICINE SLEEP, 31 (5), pp. 608-617.

    Abstract

    Study Objectives: Individual sleep timing differs and is governed partly by circadian oscillators, which may be assessed by hormonal markers, or by clock gene expression. Clock gene expression oscillates in peripheral tissues, including leukocytes. The study objective was to determine whether the endogenous phase of these rhythms, assessed in the absence of the sleep-wake and light-dark cycle, correlates with habitual sleep-wake timing. Design: Observational, cross-sectional. Setting: Home environment and Clinical Research Center. Participants: 24 healthy subjects aged 25.0 ± 3.5 (SD) years. Measurements: Actigraphy and sleep diaries were used to characterize sleep timing. Circadian rhythm phase and amplitude of plasma melatonin, cortisol, and BMAL1, PER2, and PER3 expression were assessed during a constant routine. Results: Circadian oscillations were more robust for PER3 than for BMAL1 or PER2. Average peak timings were 6:05 for PER3, 8:06 for PER2, 15:06 for BMAL1, 4:20 for melatonin, and 10:49 for cortisol. Individual sleep-wake timing correlated with the phases of melatonin and cortisol. Individual PER3 rhythms correlated significantly with sleep-wake timing and the timing of melatonin and cortisol, but those of PER2 and BMAL1 did not reach significance. The correlation between sleep timing and PER3 expression was stronger in individuals homozygous for the variant of the PER3 polymorphism that is associated with morningness. Conclusions: Individual phase differences in PER3 expression during a constant routine correlate with sleep timing during entrainment. PER3 expression in leukocytes represents a useful molecular marker of the circadian processes governing sleep-wake timing.

  • Viola AU, Archer SN, James LM, Groeger JA, Lo JCY, Skene DJ, von Schantz M, Dijk D-J. (2007) 'PER3 polymorphism predicts sleep structure and waking performance'. CELL PRESS CURRENT BIOLOGY, 17 (7), pp. 613-618.
  • Jones KHS, Ellis J, Von Schantz M, Skene DJ, Dijk D-J, Archer SN. (2007) 'Age-related change in the association between a polymorphism in the PER3 gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 16 (1), pp. 12-16.
  • Hogben AL, Ellis J, Archer SN, von Schantz M. (2007) 'Conscientiousness is a predictor of diurnal preference.'. Chronobiol Int, United States: 24 (6), pp. 1249-1254.

    Abstract

    The relationship between diurnal preference, as measured by the Horne-Ostberg questionnaire, and quantifiable personality traits was investigated in 617 participants. A hierarchical multiple regression analysis demonstrated that out of the personality variables, conscientiousness was the single biggest predictor of diurnal preference (beta=0.246), after controlling for depression, sleep disorders, shift work, age, gender, and demographic characteristics. Morningness has previously been associated with physiological parameters of the circadian clock and with polymorphisms in circadian clock genes, suggesting the possibility that conscientiousness, too, may be linked to the same parameters.

  • von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. SPRINGER JOURNAL OF MOLECULAR EVOLUTION, 62 (6), pp. 701-707.
  • Carpen JD, von Schantz M, Smits M, Skene DJ, Archer SN. (2006) 'A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans'. SPRINGER TOKYO JOURNAL OF HUMAN GENETICS, 51 (12), pp. 1122-1125.
  • Von Schantz M, Jenkins A, Archer SN. (2006) 'Evolutionary history of the vertebrate Period genes'. Journal of Molecular Evolution, 62 (6), pp. 701-707.
  • Nadkarni NA, Weale ME, von Schantz M, Thomas MG. (2005) 'Evolution of a length polymorphism in the human PER3 gene, a component of the circadian system'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 20 (6), pp. 490-499.
  • Jenkins A, Archer SN, von Schantz M. (2005) 'Expansion during primate radiation of a variable number tandem repeat in the coding region of the circadian clock gene Period3'. SAGE PUBLICATIONS LTD JOURNAL OF BIOLOGICAL RHYTHMS, 20 (5), pp. 470-472.
  • Carpen JD, Archer SN, Skene DJ, Smits M, von Schantz M. (2005) 'A single-nucleotide polymorphism in the 5 '-untranslated region of the hPER2 gene is associated with diurnal preference'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, 14 (3), pp. 293-297.
  • Dijk DJ, von Schantz M. (2005) 'Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators'. SAGE PUBLICATIONS INC JOURNAL OF BIOLOGICAL RHYTHMS, 20 (4), pp. 279-290.
  • Archer SN, Ahuja P, Caffe R, Mikol C, Foster RG, van Veen T, von Schantz M. (2004) 'Absence of phosphoglucose isomerase-1 in retinal photoreceptor, pigment epithelium and Muller cells'. BLACKWELL PUBLISHING LTD EUROPEAN JOURNAL OF NEUROSCIENCE, 19 (11), pp. 2923-2930.
  • von Schantz M, Archer SN. (2003) 'Clocks, genes and sleep'. ROYAL SOC MEDICINE PRESS LTD JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 96 (10), pp. 486-489.
  • Archer SN, Robilliard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. AMER ACAD SLEEP MEDICINE SLEEP, 26 (4), pp. 413-415.
  • Robilliard DL, Archer SN, Arendt J, Lockley SW, Hack LM, English J, Leger D, Smits MG, Williams A, Skene DJ, von Schantz M. (2002) 'The 3111 Clock gene polymorphism is not associated with sleep and circadian rhythmicity in phenotypically characterized human subjects'. BLACKWELL PUBLISHING LTD JOURNAL OF SLEEP RESEARCH, 11 (4), pp. 305-312.
  • von Schantz M, Provencio I, Foster RG. (2000) 'Recent developments in circadian photoreception: More than meets the eye'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 41 (7), pp. 1605-1607.
  • Archer SN, Thompson S, Lucas RJ, Foster RG, von Schantz M. (2000) 'Analysis of differentially expressed genes in the wildtype and rd mouse retina by macroarray screening.'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 41 (4), pp. S27-S27.
  • Gao N, von Schantz M, Foster RG, Hardie J. (1999) 'The putative brain photoperiodic photoreceptors in the vetch aphid, Megoura viciae'. PERGAMON-ELSEVIER SCIENCE LTD JOURNAL OF INSECT PHYSIOLOGY, 45 (11), pp. 1011-1019.
  • von Schantz M, Lucas RJ, Foster RG. (1999) 'Circadian oscillation of photopigment transcript levels in the mouse retina'. ELSEVIER SCIENCE BV MOLECULAR BRAIN RESEARCH, 72 (1), pp. 108-114.
  • Freedman MS, Lucas RJ, Soni B, von Schantz M, Munoz M, David-Gray Z, Foster R. (1999) 'Regulation of mammalian circadian behavior by non-rod, non-cone, ocular photoreceptors'. AMER ASSOC ADVANCEMENT SCIENCE SCIENCE, 284 (5413), pp. 502-504.
  • Lockley SW, Skene DJ, Thapan K, English J, Ribeiro D, Haimov I, Hampton S, Middleton B, von Schantz M, Arendt J. (1998) 'Extraocular light exposure does not suppress plasma melatonin in humans'. ENDOCRINE SOC JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 83 (9), pp. 3369-3372.
  • von Schantz M, Szel A, van Veen T, Farber DB. (1998) 'Cloning of a cyclic GMP phosphodiesterase gamma subunit from the ground squirrel retina'. ELSEVIER SCIENCE BV MOLECULAR BRAIN RESEARCH, 54 (2), pp. 327-333.

Conference papers

  • Lazar A, Santhi N, Lo J, Slak A, Hasan S, Von Schantz M, Archer S, Dijk D-J. (2012) 'The circadian and homeostatic regulation of sleep spindle activity: effect of the PER3 VNTR polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 82-82.
  • Groeger JA, Lo JC, Santhi N, Arbon EL, Lazar A, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) ''Trait-like' susceptibility to sleep loss varies with circadian phase and the task used to index vulnerable-resilient sleep-deprived performance'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 36-37.
  • Lo JC, Groeger JA, Santhi N, Arbon EL, Lazar AS, Hasan S, Von Schantz M, Archer SN, Dijk DJ. (2012) 'Effects of circadian phase and prior partial sleep deprivation on executive functions during total sleep deprivation are modulated by PER3 polymorphism'. WILEY-BLACKWELL JOURNAL OF SLEEP RESEARCH, Paris, FRANCE: 21st Congress of the European-Sleep-Research-Society 21, pp. 41-41.
  • Archer S, Viola A, Von Schantz M, Dijk D. (2007) 'Endogenous circadian rhythm of PER3 RNA in human leucocytes: Association with sleep timing, melatonin rhythm, and PER3 genotype'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A55.
  • Groeger J, Lo J, Viola A, Von Schantz M, Archer S, Dijk D. (2007) 'PER3 polymorphism predictssusceptibility to sleep deprivation-induced impairment of early morning executive performance'. AMER ACADEMY SLEEP MEDICINE SLEEP, Minneapolis, MN: 21st Annual Meeting of the Association-Professional-Sleep-Societies 30, pp. A54-A54.
  • Von Schantz M, Archer SN. (2006) 'Genetic aspects of delayed sleep phase syndrome (DSPS)'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 5-5.
  • Viola AU, Archer SN, Groeger JA, Skene DJ, Von Schantz M, Dijk DJ. (2006) 'Polymorphism in the clock gene PER3 predicts sleep structure and EEG power spectra'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 53-53.
  • Jones KH, Ellis J, Von Schantz M, Skene DJ, Dijk D, Archer SN. (2006) 'Age-related change in the association between a variable number tandem repeat polymorphism in the (PER3) gene and preferred timing of sleep and waking activities'. BLACKWELL PUBLISHING JOURNAL OF SLEEP RESEARCH, Innsbruck, AUSTRIA: 18th Congress of the European-Sleep-Research-Society 15, pp. 97-98.
  • Archer SN, Robillard DL, Skene DJ, Smits M, Williams A, Arendt J, von Schantz M. (2003) 'A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference'. AMER ACADEMY SLEEP MEDICINE SLEEP, CHICAGO, ILLINOIS: 17th Annual Meeting of the Associated-Professional-Sleep-Societies 26, pp. A109-A109.
  • Ahuja P, Archer SN, van Veen T, von Schantz M. (2003) 'Neuroleukin/AMF is present around cones and in various spatially restricted cell types of the mouse retina'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, FT LAUDERDALE, FLORIDA: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology 44, pp. U459-U459.
  • von Schantz M, Archer SN, Ahuja P, van Veen T. (2002) 'Identification of transcripts enriched in the inner retina by differential macroarray hybridization'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, FT LAUDERDALE, FLORIDA: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology 43, pp. U321-U321.
  • Archer SN, Lucas RJ, Thompson S, Foster RG, von Schantz M. (2002) 'Identification of a novel retinal kinase with promoter elements affected by circadian clock proteins'. ASSOC RESEARCH VISION OPHTHALMOLOGY INC INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, FT LAUDERDALE, FLORIDA: Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology 43, pp. U308-U308.
  • Lockley SW, Skene DJ, Thapan K, English J, Ribeiro D, von Schantz M, Arendt J, Holick MF, Jung EG. (1999) 'Extraocular light exposure does not suppress plasma melatonin in humans'. SPRINGER BIOLOGIC EFFECTS OF LIGHT 1998, BASEL, SWITZERLAND: 5th International Arnold Rikli Symposium on the Biologic Effects of Light, pp. 403-406.

Teaching

  • Level 1:
    • BMS1008 Physiology
  • Level 2:
    • BMS2003 Molecular Biology and Genetics (Module Coordinator)
    • BMS2008 Pathology & Medicine
    • BMS2018 Key Skills (Module Coordinator)
    • BMS2025 Neuroscience (Module Coordinator)
  • Level 3:
    • BMS3008 Neuroendocrinology
    • BMS3034 Biological Rhythms
    • BMS3038 Human and Medical Genetics
    • BMS3042 Neuroscience: From Molecules to Mind

Departmental Duties

  • Programme Organiser, MSc Clinical Biochemistry (until September 2009)
  • Senior PTY Tutor (Overseas placements)
  • Associate Dean (International Relations, from September 2009)
  • Bioscience Erasmus Coordinator (from September 2009)
  • Bioscience Library Representative
  • Member of Senate

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