Dr Nicola Annels

Research Fellow

Qualifications: BSc PhD

Email:
Phone: Work: 01483 68 8562
Room no: 09 PGM 02

Office hours

9am to 5pm Monday-Friday

Further information

Biography

1992-1995     B.Sc. Upper Second Class (Hons), Biological Sciences, University of Southampton, UK

 

1995-1999     PhD., University of Birmingham, Immunology

   Under the supervision of Prof. Alan Rickinson my research focused on CD8+ T cell responses to     Epstein-Barr Virus (EBV) antigens.

 

1999-2000     Postdoctoral researcher, CRC Institute for Cancer Studies, University of Birmingham,        Edgbaston, Birmingham, UK

                        The research followed on from my PhD using Epstein Barr virus as a model system in which to         investigate the establishment of immunological memory

 

2000-2007     Postdoctoral Fellow, Leiden University Medical Center, Paediatrics, Leiden, The Netherlands

                        My project involved the identification of the homing receptor profiles and functional characterization of T cells involved in the pathogenesis and regulation of acute GvHD. In addition, I also collaborated with Prof. R.Maarten Egeler on a project trying to elucidate the pathophysiology and etiology of Langerhans cell histiocytosis.

 

2007-to date Senior Postdoctoral Fellow, Postgraduate Medical School, University of Surrey, Guildford, UK

                        I currently oversee the immunological research in the Oncology group headed by Prof Hardev Pandha. Our research projects focus on developing new immunotherapeutic strategies to treat cancer patients. This involves both the identification of novel immunotherapeutic target antigens as well as developing new strategies to abrogate the immunosuppressive mechanisms active in cancer.

 

Research Interests

Main interests are in tumour immunology, immunotherapy and regulatory T cells

 

Publications

Journal articles

  • Annels NE, Simpson GR, Denyer M, McGrath SE, Falgari G, Killick E, Eeles R, Stebbing J, Pchejetski D, Cutress R, Murray N, Michael A, Pandha H. (2014) 'Spontaneous antibodies against Engrailed-2 (EN2) protein in patients with prostate cancer.'. Clin Exp Immunol,
  • Annels NE, Shaw VE, Gabitass RF, Billingham L, Corrie P, Eatock M, Valle J, Smith D, Wadsley J, Cunningham D, Pandha H, Neoptolemos JP, Middleton G. (2013) 'The effects of gemcitabine and capecitabine combination chemotherapy and of low-dose adjuvant GM-CSF on the levels of myeloid-derived suppressor cells in patients with advanced pancreatic cancer.'. Cancer Immunol Immunother,
  • Michael A, Relph K, Annels N, Pandha H. (2013) 'Prostate cancer vaccines.'. Expert Rev Vaccines, England: 12 (3), pp. 253-262.

    Abstract

    In 2010, the US FDA approved the first therapeutic cancer vaccine for the treatment of castration refractory prostate cancer - sipuleucel-T. Prostate cancer is an ideal model for cancer vaccine development based on the ready demonstration of humoral and cellular immunity to a range of cancer antigens as well as often slow progression which means that patients who are otherwise well may have a radiologically evaluable minor progression, after conventional treatment and can undergo vaccine therapy over sufficient periods of time, so as to allow the generation of a robust antitumor response. The association of prostate cancer with one of the few serum cancer biomarkers in general use has also allowed assessment of response and risk stratification of patients. In this review, we will examine key aspects of the evolution of prostate cancer vaccines, which provides an accurate prototype for other cancers, and the challenges we face.

  • Simpson GR, Horvath A, Annels NE, Pencavel T, Metcalf S, Seth R, Peschard P, Price T, Coffin RS, Mostafid H, Melcher AA, Harrington KJ, Pandha HS. (2012) 'Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer'. BRITISH JOURNAL OF CANCER, 106 (3), pp. 496-507.
  • Middleton GW, Annels NE, Pandha HS. (2012) 'Are we ready to start studies of Th17 cell manipulation as a therapy for cancer?'. Cancer Immunol Immunother, Germany: 61 (1), pp. 1-7.
  • Gabitass RF, Annels NE, Stocken DD, Pandha HA, Middleton GW. (2011) 'Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13.'. Cancer Immunol Immunother,
  • Morgan R, Boxall A, Bhatt A, Bailey M, Hindley R, Langley S, Whitaker HC, Neal DE, Ismail M, Whitaker H, Annels N, Michael A, Pandha H. (2011) 'Engrailed-2 (EN2): a tumor specific urinary biomarker for the early diagnosis of prostate cancer.'. Clin Cancer Res, United States: 17 (5), pp. 1090-1098.

    Abstract

    Prostate cancer (PC) is the second most common cause of cancer related death in men. A number of key limitations with prostate specific antigen (PSA), currently the standard detection test, has justified evaluation of new biomarkers. We have assessed the diagnostic potential of Engrailed-2 (EN2) protein, a homeodomain-containing transcription factor expressed in PC cell lines and secreted into the urine by PC in men.

  • Gabitass RF, Annels NE, Pandha HA, Middleton GW, Stocken DD. (2011) 'Elevated myeloid-derived suppressor cells in pancreatic, esophageal and gastric cancer are an independent prognostic factor and are associated with significant elevation of the Th2 cytokine interleukin-13'. Cancer Immunology, Immunotherapy, 60 (10), pp. 1419-1430.
  • Heinemann L, Simpson GR, Annels NE, Vile R, Melcher A, Prestwich R, Harrington KJ, Pandha HS. (2010) 'The Effect of Cell Cycle Synchronization on Tumor Sensitivity to Reovirus Oncolysis'. NATURE PUBLISHING GROUP MOLECULAR THERAPY, 18 (12), pp. 2085-2093.
  • Faaij CMJM, Willemze AJ, Revesz T, Balzarolo M, Tensen CP, Hoogeboom M, Vermeer MH, van Wering E, Zwaan CM, Kaspers GJL, Story C, van Halteren AGS, Vossen JM, Egeler RM, van Tol MJD, Annels NE. (2010) 'Chemokine/Chemokine Receptor Interactions in Extramedullary Leukaemia of the Skin in Childhood AML: Differential Roles for CCR2, CCR5, CXCR4 and CXCR7'. WILEY-LISS PEDIATRIC BLOOD & CANCER, 55 (2), pp. 344-348.
  • Faaij CM, Annels NE, Ruigrok G, van der Burg M, Ball LM, Bredius RG, van Tol MJ, Lankester AC. (2010) 'Decrease of Skin Infiltrating and Circulating CCR10+T Cells Coincides with Clinical Improvement after Topical Tacrolimus in Omenn Syndrome'. NATURE PUBLISHING GROUP JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130 (1), pp. 308-311.
  • Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter JI, Arico M, Delprat C. (2009) 'LANGERHANS CELL HISTIOCYTOSIS REVEALS A NEW IL-17A-DEPENDENT PATHWAY OF DENDRITIC CELL FUSION'. WILEY-LISS PEDIATR BLOOD CANCER, 53 (4), pp. 686-686.
  • da Costa CET, Szuhai K, van Eijk R, Hoogeboom M, Sciot R, Mertens F, Bjorgvinsdottir H, Debiec-Rychter M, de Krijger RR, Hogendoorn PCW, Egeler RM, Annels NE. (2009) 'No Genomic Aberrations in Langerhans Cell Histiocytosis as Assessed by Diverse Molecular Technologies'. WILEY-LISS GENES CHROMOSOMES & CANCER, 48 (3), pp. 239-249.
  • Coury F, Annels N, Rivollier A, Olsson S, Santoro A, Speziani C, Azocar O, Flacher M, Djebali S, Tebib J, Brytting M, Egeler RM, Rabourdin-Combe C, Henter J-I, Arico M, Delprat C. (2008) 'Langerhans cell histiocytosis reveals a new IL-17A dependent pathway of dendritic cell fusion'. NATURE PUBLISHING GROUP NATURE MEDICINE, 14 (1), pp. 81-87.
  • Costa C, Annels N, Hoogeboom M, Szuhai K, Hogendoorn P, Egeler M. (2007) 'Investigation of potential chromosomal abnormalities in the lesional cells of Langerhans cell histiocytosis'. WILEY-LISS PEDIATRIC BLOOD & CANCER, 48 (7), pp. 753-754.
  • da Costa CET, Egeler RM, Hoogeboorn M, Szuhai K, Forsyth RG, Niesters M, de Krijger RR, Tazi A, Hogendoorn PCW, Annels NE. (2007) 'Differences in telomerase expression by the CD1a(+) cells in Langerhans cell histiocytosis reflect the diverse clinical presentation of the disease'. JOHN WILEY & SONS LTD JOURNAL OF PATHOLOGY, 212 (2), pp. 188-197.
  • Annels NE, Kalpoe JS, Bredius RGM, Claas EC, Kroes ACM, Hislop AD, van Baarle D, Egeler RM, van Tol MJD, Lankester AC. (2006) 'Management of Epstein-Barr virus (EBV) reactivation after allogeneic stem cell transplantation by simultaneous analysis of EBV DNA load and EBV-specific T cell reconstitution'. UNIV CHICAGO PRESS CLINICAL INFECTIOUS DISEASES, 42 (12), pp. 1743-1748.
  • Faaij CMJM, Lankester AC, Spierings E, Hoogeboom M, Bowman EP, Bierings M, Revesz T, Egeler RM, van Tol MJD, Annels NE. (2006) 'A possible role for CCL27/CTACK-CCR10 interaction in recruiting CD4(+) T cells to skin in human graft-versus-host disease'. BLACKWELL PUBLISHING BRITISH JOURNAL OF HAEMATOLOGY, 133 (5), pp. 538-549.
  • da Costa CET, Annels NE, Faaij CMJM, Forsyth RG, Hogendoorn PCW, Egeler RM. (2005) 'Presence of osteoclast-like multinucleated giant cells in the bone and nonostotic lesions of Langerhans cell histiocytosis'. ROCKEFELLER UNIV PRESS JOURNAL OF EXPERIMENTAL MEDICINE, 201 (5), pp. 687-693.
  • Costa C, Annels NE, Faaij C, Hoogendorn P, Egeler RM. (2004) 'The role of multinucleated giant cells in Langerhans cell histiocytosis'. WILEY-LISS PEDIATRIC BLOOD & CANCER, 43 (2), pp. 199-199.
  • Egeler RM, Annels NE, Hogendoorn PCW. (2004) 'Commentary - Langerhans cell histiocytosis: A pathologic combination of oncogenesis and immune dysregulation'. WILEY-LISS PEDIATRIC BLOOD & CANCER, 42 (5), pp. 401-403.
  • Annels NE, Willemze AJ, van der Velden VHJ, Faaij CMJM, van Wering E, Sie-Go DMDS, Egeler RM, van Tol MJD, Revesz T. (2004) 'Possible link between unique chemokine and homing receptor expression at diagnosis and relapse location in a patient with childhood T-ALL'. AMER SOC HEMATOLOGY BLOOD, 103 (7), pp. 2806-2808.
  • Egeler RM, Laman JD, Leenen PJM, Annels NE, Hogendoorn PCW. (2003) 'Response to Fadeel and Henter: Langerhans cell histiocytosis: a combination of carcinogenesis and inflammation'. ELSEVIER SCI LTD TRENDS IN IMMUNOLOGY, 24 (8), pp. 410-411.
  • Annels NE, da Costa CET, Prins FA, Willemze A, Hogendoorn PCW, Egeler RM. (2003) 'Aberrant chemokine receptor expression and chemokine production by Langerhans cells underlies the pathogenesis of Langerhans cell histiocytosis'. ROCKEFELLER UNIV PRESS JOURNAL OF EXPERIMENTAL MEDICINE, 197 (10), pp. 1385-1390.
  • Laman JD, Leenen PJM, Annels NE, Hogendoorn PCW, Egeler RM. (2003) 'Langerhans-cell histiocytosis 'insight into DC biology''. ELSEVIER SCI LTD TRENDS IN IMMUNOLOGY, 24 (4), pp. 190-196.
  • Dunne PJ, Faint JM, Gudgeon NH, Fletcher JM, Plunkett FJ, Scares MVD, Hislop AD, Annels NE, Rickinson AB, Salmon M, Akbar AN. (2002) 'Epstein-Barr virus-specific CD8(+) T cells that re-express CD45RA are apoptosis-resistant memory cells that retain replicative potential'. AMER SOC HEMATOLOGY BLOOD, 100 (3), pp. 933-940.
  • Hislop AD, Annels NE, Gudgeon NH, Leese AM, Rickinson AB. (2002) 'Epitope-specific evolution of human CD8(+) T cell responses from primary to persistent phases of Epstein-Barr virus infection'. ROCKEFELLER UNIV PRESS JOURNAL OF EXPERIMENTAL MEDICINE, 195 (7), pp. 893-905.
  • Faint JM, Annels NE, Curnow SJ, Shields P, Pilling D, Hislop AD, Wu LJ, Akbar AN, Buckley CD, Moss PAH, Adams DH, Rickinson AB, Salmon M. (2001) 'Memory T cells constitute a subset of the human CD8(+)CD45RA(+) pool with distinct phenotypic and migratory characteristics'. AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY, 167 (1), pp. 212-220.
  • Annels NE, Callan MFC, Tan L, Rickinson AB. (2000) 'Changing patterns of dominant TCR usage with maturation of an EBV-specific cytotoxic T cell response'. AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY, 165 (9), pp. 4831-4841.
  • Tan LC, Gudgeon N, Annels NE, Hansasuta P, O'Callaghan CA, Rowland-Jones S, McMichael AJ, Rickinson AB, Callan MFC. (1999) 'A re-evaluation of the frequency of CD8(+) T cells specific for EBV in healthy virus carriers'. AMER ASSOC IMMUNOLOGISTS JOURNAL OF IMMUNOLOGY, 162 (3), pp. 1827-1835.
  • Steven NM, Annels NE, Kumar A, Leese AM, Kurilla MG, Rickinson AB. (1997) 'Immediate early and early lytic cycle proteins are frequent targets of the Epstein-Barr virus-induced cytotoxic T cell response'. ROCKEFELLER UNIV PRESS JOURNAL OF EXPERIMENTAL MEDICINE, 185 (9), pp. 1605-1617.
  • Steven NM, Leese AM, Annels NE, Lee SP, Rickinson AB. (1996) 'Epitope focusing in the primary cytotoxic T cell response to Epstein-Barr virus and its relationship to T cell memory'. ROCKEFELLER UNIV PRESS JOURNAL OF EXPERIMENTAL MEDICINE, 184 (5), pp. 1801-1813.

Conference papers

  • Annels NE, Simpson GR, Bokaee S, Riley C, Denyer M, Pandha H, Morgan R. (2012) 'Modulation of Regulatory T Cells by Targeting The NFAT-FOXP3 Protein: Protein Interaction'. LIPPINCOTT WILLIAMS & WILKINS JOURNAL OF IMMUNOTHERAPY, North Bethesda, MD: 27th Annual Scientific Meeting of the Society-for-Immunotherapy-of-Cancer (SITC) 35 (9), pp. 775-775.
  • McGrath S, Annels NE, Madhuri TK, Haagsma B, Larbi ED, Pandha HS, Michael A. (2012) 'Engrailed protein: A cancer-specific marker in epithelial ovarian cancer'. AMER SOC CLINICAL ONCOLOGY JOURNAL OF CLINICAL ONCOLOGY, Chicago, IL: 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) 30 (15)
  • Killick E, Morgan R, Launchbury F, Annels NE, Bancroft E, Page E, Castro E, Kote-Jarai Z, Eeles RA, Pandha HS. (2012) 'Detecting prostate cancer in BRCA1 and BRCA2 mutation carriers: A role for EN2?'. AMER SOC CLINICAL ONCOLOGY JOURNAL OF CLINICAL ONCOLOGY, Chicago, IL: 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO) 30 (15)
  • Michael A, Riley, C, Bokaee S, Denyer M, Pandha H, Annels N. (2011) 'EN2: A candidate antigen for the development of targeted therapies in ovarian cancer.'. JCO, Chicago: ASCO (J Clin Oncol 29: 2011 (suppl; abstr e15528))
  • Ismail MI, Bokaee S, Annels N, Davies J, Pandha H. (2011) 'Predominance of CD8 T cell infiltration coincides with reciprocal reduction in regulatory T cells following prostate cryotherapy'. WILEY-BLACKWELL BRITISH JOURNAL OF SURGERY, Royal Coll Surgery, Dublin, IRELAND: Annual Meeting of the Society-of-Academic-and-Research-Surgery 98, pp. 48-48.
  • Simpson GR, Horvath A, Harrington K, Coffin RS, Pandha H. (2008) 'Combination of a fusogenic glycoprotein, pro-drug activation and oncolytic HSV as an intravesical therapy for superficial bladder cancer'. PERGAMON-ELSEVIER SCIENCE LTD EJC SUPPLEMENTS, Geneva, SWITZERLAND: 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics 6 (12), pp. 97-98.
  • Costa C, Egeler M, Forsyth R, Szuhai K, Niesters M, de Krijger R, Tati A, Hogendoorn P, Annels N. (2007) 'Differences in telomerase expression by the CD1 a+ cells in langerhans cell histiocytosis reflects the diverse clinical presentation of the disease'. ACADEMIC PRESS INC ELSEVIER SCIENCE CLINICAL IMMUNOLOGY, San Diego, CA: 7th Annual Meeting of the Federation-of-Clinical-Immunology-Societies 123, pp. S50-S50.
  • Faaij C, Annels N, van den Burg M, Langerak A, Ruigrok G, Bowman E, van Tol M, Lankester A. (2006) 'Identification of a clonal population of CCR10+ skin-homing T-cells in an Omenn Syndrome patient.'. ACADEMIC PRESS INC ELSEVIER SCIENCE CLINICAL IMMUNOLOGY, San Francisco, CA: 6th Annual Meeting of the Federation-of-Clinical-Immunology-Societies 119, pp. S128-S129.
  • Faaij CMJM, Annels NE, Zuidwijk K, Lankester AC, Revesz T, Bierings M, Egeler RM, van Tol MJD. (2005) 'Possible involvement of CCL28 in the localisation of CCR3+T-cells in intestinal GvHD'. NATURE PUBLISHING GROUP BONE MARROW TRANSPLANTATION, Prague, CZECH REPUBLIC: 31st Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation/21st Meeting of the EBMT-Nurses-Group/4th Meeting of the EBMT-Data-Management-Group 35, pp. S134-S134.
  • Annels NE, Faaij CMJM, Lankester AC, Spierings E, Schilham MW, Bowman EP, Bierings M, Revesz T, Egeler RM, Leiden MJDV. (2005) 'Identification Of a skin-homing population of CD4+T cells in patients with skin GvHD'. NATURE PUBLISHING GROUP BONE MARROW TRANSPLANTATION, Prague, CZECH REPUBLIC: 31st Annual Meeting of the European-Group-for-Blood-and-Marrow-Transplantation/21st Meeting of the EBMT-Nurses-Group/4th Meeting of the EBMT-Data-Management-Group 35, pp. S134-S135.
  • Rickinson AB, Callan MFC, Annels NE. (2000) 'T-cell memory: lessons from Epstein-Barr virus infection in man'. ROYAL SOC LONDON PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, LONDON, ENGLAND: Synposium on Immunological Memory 355 (1395), pp. 391-400.

Page Owner: na0010
Page Created: Tuesday 3 January 2012 11:23:26 by pr0004
Last Modified: Monday 16 January 2012 14:36:05 by na0010
Expiry Date: Saturday 27 November 2010 15:58:24
Assembly date: Tue Apr 15 22:21:55 BST 2014
Content ID: 70660
Revision: 2
Community: 1196