Dr Lisiane Meira
Lecturer in Toxicology
Qualifications: BSc, PhD
Phone: Work: 01483 68 6449
Room no: 13A AY 04
9 am to 5 pm
- 1988 B.Sc., Biology. Federal University of Rio Grande do Sul, Porto Alegre/Brazil.
- 1994 Ph.D., Genetics and Molecular Biology. Curie Institute, Paris/France & UFRGS, Porto Alegre/Brazil.
- 1995-2000 Postdoctoral Research Fellow/Instructor, UT Southwestern Medical Center, Texas, USA
- 2001-2008 Research Scientist, Harvard School of Public Health/Massachusetts Institute of Technology, MA, USA
- 2008-2009 Research Fellow, St. George’s University of London
- 2009-current Lecturer in Toxicology, University of Surrey
My research focuses on understanding the mechanisms by which exposures to endogenous and/or exogenous toxicants lead to pathology and disease. In particular, I am interested in understanding how defective repair of DNA damage can affect health, with implications to human degenerative diseases associated with aging such as cancer and neuronal degeneration.
Meira LB, Moroski-Erkul CA, Green SL, Calvo JA, Bronson RT, Shah D, Samson LD (2009) Aag-initiated base excision repair drives alkylation-induced retinal degeneration in mice. Proc Natl Acad Sci U S A. 106(3):888-93.
Klapacz J, Meira LB, Luchetti DG, Calvo JA, Bronson RT, Edelmann W, Samson LD. (2009) O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo. Proc Natl Acad Sci U S A. 106(2):576-81.
Bugni, JM, Meira, LB, Samson, LD (2009) Alkylation-induced colon tumorigenesis in mice deficient in the Mgmt and Msh6 proteins. Oncogene 2009 Feb 5;28(5):734-412.
Maor-Shoshani, A, Meira, LB, Yang, X, Samson, LD (2008) 3-Methyladenine DNA glycosylase is important for cellular resistance to psoralen interstrand cross-links. DNA Repair. 7:1399-1406
Meira LB, Bugni JM, Green SL, Lee CW, Pang B, Borenshtein D, Rickman BH, Rogers AB, Moroski-Erkul CA, McFaline JL, Schauer DB, Dedon PC, Fox JG, Samson LD (2008) DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice. J. Clin. Invest. 118:2516-2525
Ringvoll J, Moen MN, Nordstrand LM, Meira LB, Pang B, Bekkelund A, Dedon PC, Bjelland S, Samson LD, Falnes PØ, Klungland A (2008) AlkB homologue 2-mediated repair of ethenoadenine lesions in mammalian DNA. Cancer Res. 68:4142-4149.
Lingaraju, GM, Kartalou, M, Meira, LB, Samson, LD. (2008) Substrate specificity and sequence-dependent activity of the Saccharomyces cerevisiae 3-methyladenine DNA glycosylase (Mag). DNA Repair. 7:970-982.
Longerich, S, Meira, LB, Shah, D, Samson, LD and U Storb (2007) Alkyladenine DNA glycosylase (Aag) in somatic hypermutation and class switch recombination. DNA Repair. 6:1764-1773.
Dong, L, Meira, LB, Hazra, TK, Samson, LD and W Cao (2007) Oxanine DNA glycosylase activities in mammalian systems. DNA Repair. 1;7(1):128-34.
Beyer, RP, Fry, RC, Lasarev, MR, McConnachie, LA, Meira, LB, Palmer, VS, Powell, CL, Ross, PK, Bammler, TK, Bradford, BU, Cranson, AB, Cunningham, ML, Fannin, RD, Higgins, GM, Hurban, P, Kayton, RJ, Kerr, KF, Kosyk, O, Lobenhofer, EK, Sieber, SO, Vliet, PA, Weis, BK, Wolfinger, R, Woods, CG, Freedman, JH, Linney, E, Kaufmann, WK, Kavanagh, TJ, Paules, RS, Rusyn, I, Samson, LD, Spencer, PS, Suk, W, Tennant, RJ, Zarbl, H, Members of the Toxicogenomics Research Consortium (2007) Multicenter study of acetaminophen hepatotoxicity reveals the importance of biological endpoints in genomic analyses Toxicol. Sci. 99: 326-337.
MSc Toxicology: TOX M001, TOX M007, TOX M009
Undergraduate lecture notes
Biosciences Library Representative