Biography

2002 – present, . Professor of Molecular Genetics, University of Surrey
1994 – 2001 Reader, School of Biological Sciences, University of Surrey.
1988-94 Lecturer, School of Biological Sciences, University of Surrey.
1984-88 Research Fellow. Department of Surgery, St. George's Hospital Medical School, London.
1982-84 Research Fellow, Department of Biochemistry, St. Mary's Hospital Medical School, London.

1982: PhD (Biochemistry) Imperial College, University of London

1978 BSc (Biochemistry) Bedford College, University of London

Research Interests

Systems Biology

Mycobacterial genetics

Pathogenicity of tuberculosis

Neisserial genetics

Pathogenicity of meningococcal meningitis

Bionanotechnology

Research Collaborations

CARBIO network: Marie Curie Research Training Network - Multifunctional Carbon Nanotubes for Biomedical Applications

Graham Stewart

Andrzej Kierzek

Publications

1. Heister, E., Neves, V., Tîlmaciu, C., Lipert, K., Sanz Beltrán, V., Helen Coley, C., Silva, R.S.P and McFadden, J. (2009) Triple functionalisation of single-walled carbon nanotubes with doxorubicin, a monoclonal antibody, and a fluorescent marker for targeted cancer therapy. Carbon, in press: doi:10.1016/j.carbon.2009.03.057
2. Mendum, T, Newcombe, J., McNeilly, C. and McFadden, J. (2009) Towards the Immunoproteome of Neisseria meningitidis. PLoS ONE 4(6): e5940. doi:10.1371/journal.pone.0005940
3. Beste, D., M. Espasa, B. Bonde, A. M. Kierzek, G.R. Stewart and J.J. McFadden. (2009) The genetic requirements for fast and slow growth in mycobacteria. PlosOne: http://dx.plos.org/10.1371/journal.pone.0005349.
4. R. H. Senaratne, B. Sidders, P. Sequeira, G. Saunders, K. Dunphy, O. Marjanovic, J. R. Reader, P. Lima, S. Chan, S. Kendall, J. McFadden, and L. W. Riley. (2008) Mycobacterium tuberculosis strains disrupted in mce3 and mce4 operons are attenuated in mice. J.Med.Microbiol. 57 (Pt 2):164-170.
5. Beste,D., Hooper,T., Stewart,G.S., Bonde,B., Avignone-Rossa,C., Bushell,M., Wheeler,P.R., Klamt,S., Kierzek,A.M., and McFadden,J.J. (2007). GSMN-TB: a web-based genome scale network model of Mycobacterium tuberculosis metabolism. Genome Biol 8, R89.
6. S. Borsuk, T. A. Mendum, M. Q. Fagundes, M. Michelon, C. W. Cunha, J. McFadden, and O. A. Dellagostin. (2007) Auxotrophic complementation as a selectable marker for stable expression of foreign antigens in Mycobacterium bovis BCG. Tuberculosis.(Edinb.) 87 (6):474-480.
7. Beste,D.J., Laing,E., Bonde,B., Avignone-Rossa,C., Bushell,M.E., and McFadden,J.J. (2007). Transcriptomic analysis identifies growth rate modulation as a component of the adaptation of mycobacteria to survival inside the macrophage. J. Bacteriol. 189, 3969-3976.
8. Santangelo,M.P., McIntosh,D., Bigi,F., Armoa,G.R., Campos,A.S., Ruybal,P., Dellagostin,O.A., McFadden,J., Mendum,T., Gicquel,B., Winter,N., Farber,M., and Cataldi,A. (2007). Mycobacterium bovis BCG as a delivery system for the RAP-1 antigen from Babesia bovis. Vaccine 25, 1104-1113.
9. J. C. Jeynes, E. Mendoza, A. W. Chow, P. C. P. Watts, J. J. McFadden, and S. R. P. Silva (2006). Generation of Chemically Unmodified Pure Single-Walled Carbon Nanotubes by Solubilizing with RNA and Treatment with Ribonuclease A. Advanced Materials 18:1598-1602.
10. Bigi,F., Giofre,A., Klepp,L., Santaneglo,M.P., Velicovsky,C.A., Giambartolomei,G.H., Fossati,C.A., Romano,M.I., Mendum,T., McFadden,J.J., and Cataldi,A. (2005). Mutation in the P36 gene of Mycobacterium bovis provokes attenutation of the bacillus in a mouse model. Tuberculosis 85, 221-226.

Mycobacterial research

The tubercle bacillus (Mycobacterium tuberculosis) infects approximately one quarter of the world's population and is responsible for three million deaths each year.

Mycobacterial research within the Microbial Sciences Group is focussed on understanding the pathogenic mechanisms that allow Mycobacterium tuberculosis to cause about three million deaths each year, and development of new vaccines to treat the disease.

We have recently initiated a new BBSRC-funded project to develop metabolic models of the TB bacillus and use these models to predict novel drug targets, particularly in persistent organisms. A web version of our model can be found here.

We currently have a Wellcome Trust-funded vacancy (to start autumn 2009) for a bioinformaticist to develop metabolic models of the TB bacillus.

Meningococcal research