University of Surrey

Department of Nutrition and Metabolism

Green Apples lettuces Adipose Tissue

Professor Bruce Griffin

Professor of Nutritional Metabolism

Qualifications: BSc, PhD, RPHNutr

Email:
Phone: Work: 01483 68 9724
Room no: 19 AY 03

Further information

Biography

Professor Griffin is a biomedical scientist with expertise in lipid metabolism, nutritional biochemistry and cardiovascular disease. After his BSc in medical laboratory science (1984), he gained his PhD on the effects of exercise & diet on human plasma lipoproteins at the University of Aberdeen (1988), and undertook postdoctoral research in Pathological Biochemistry at Glasgow Royal Infirmary until 1994. Since then, he has held academic posts as a Lecturer, Senior lecturer, Reader and Professor of Nutritional Metabolism at the University of Surrey. He is a teacher of undergraduate dietitians, biochemists & medical students, and postgraduates in clinical biochemistry and nutritional medicine, and an active researcher in human nutrition in relation to cardiovascular health. He has published widely on the topics of lipids, dietary fat and cardiovascular risk, and has received grants for his research from the Medical Research Council, British Heart Foundation, Department for Environment Food and Rural Affairs, Food Standards Agency and Biotechnology and Biological Sciences Research Council.

Research Interests

Role of human nutrition in the pathophysiology of cardiovascular disease; effects of diet on blood lipids and lipoprotein metabolism; genetic and environmental determinants of coronary atherosclerosis.

Research studies 1996-2009

1996: Can the metabolic effects of dietary N-3 PUFA be explained by changes in the expression of lipase genes in adipose tissue?

1997: The influence of dietary N-3 PUFA on the structure, function and metabolism of TAG-rich lipoproteins in healthy individuals.

1998: Importance of alpha-linolenic acid as a source of long chain N-3 PUFA and its influence on risk factors of cardiovascular disease.

2000: Vitamin E biokinetics and metabolism in dyslipidaemia.

2000: Quantification of the optimal N-6 / N-3 ratio in the UK diet.The OPTILIP study

2003: Effect of low glycaemic index foods on blood lipids in type 2 diabetes

Impact of the amount and composition of dietary fat and carbohydrate on metabolic syndrome and CVD risk; The ‘RISCK’ Study.

2005: Effects of increased egg consumption on a weight-reducing diet on blood cholesterol & related biomarkers of CHD risk

2008: Dietary intervention study to determine the effects of prawns on serum cholesterol and related biomarkers of CHD risk

2009: How does dietary carbohydrate influence the formation of an atherogenic lipoprotein phenotype?

Research Collaborations

University of Reading, Kings College London, Imperial College London, MRC unit of Human Nutrition Research, Cambridge,

University of Glasgow, Harakopio University, Athens, Greece, Aarhus University, Denmark,

Research Collaborations

University of Reading, Kings College London, Imperial College London, MRC unit of Human Nutrition Research, Cambridge,

University of Glasgow, Harakopio University, Athens, Greece, Aarhus University, Denmark,  

Publications

Journal articles

  • Griffin BA. (2012) 'PPARγ2 gene Pro12Ala and PPARα gene Leu162Val SNPs interact with dietary intake of fat in determination of plasma lipid concentrations'. Journal of Nutrigenetics and Nutrigenomics,
  • AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB, RISCK Study Grp . (2011) 'Single nucleotide polymorphisms at the ADIPOQ gene locus interact with age and dietary intake of fat to determine serum adiponectin in subjects at risk of the metabolic syndrome'. AMER SOC CLINICAL NUTRITION AM J CLIN NUTR, 94 (1), pp. 262-269.
    doi: 10.3945/ajcn.111.014209
  • Rayman MP, Stranges S, Griffin BA, Pastor-Barriuso R, Guallar E. (2011) 'Effect of Supplementation With High-Selenium Yeast on Plasma Lipids A Randomized Trial'. AMER COLL PHYSICIANS ANN INTERN MED, 154 (10), pp. 656-W240.
    doi: 10.1059/0003-4819-154-10-201105170-00005
  • Walker CG, Goff L, Bluck LJ, Griffin BA, Jebb SA, Lovegrove JA, Sanders TAB, Frost GS, Risck Study Grp . (2011) 'Variation in the FFAR1 Gene Modifies BMI, Body Composition and Beta-Cell Function in Overweight Subjects: An Exploratory Analysis'. PUBLIC LIBRARY SCIENCE PLOS ONE, 6 (4) Article number e19146
    doi: 10.1371/journal.pone.0019146
  • Griffin BA. (2011) 'Dairy, dairy, quite contrary: further evidence to support a role for calcium in counteracting the cholesterol-raising effect of SFA in dairy foods.'. Br J Nutr, , pp. 1-2.
    doi: 10.1017/S0007114510005593
  • Toft-Petersen AP, Tilsted HH, Aaroe J, Rasmussen K, Christensen T, Griffin BA, Aardestrup IV, Andreasen A, Schmidt EB. (2011) 'Small dense LDL particles - a predictor of coronary artery disease evaluated by invasive and CT-based techniques: a case-control study'. BIOMED CENTRAL LTD LIPIDS HEALTH DIS, 10 Article number 21
    doi: 10.1186/1476-511X-10-21
  • Lovegrove JA, Griffin BA. (2011) 'Can dietary modification reduce the cardiovascular complications of metabolic syndrome? 'All for one' or 'one for all'?'. Expert Review of Cardiovascular Therapy, 9 (4), pp. 413-416.
    doi: 10.1586/erc.11.27
  • AlSaleh A, O'Dell SD, Frost GS, Griffin BA, Lovegrove JA, Jebb SA, Sanders TAB. (2011) 'Interaction of PPARG Pro12Ala with dietary fat influences plasma lipids in subjects at cardiometabolic risk'. Journal of Lipid Research, 52 (12), pp. 2298-2303.
  • Griffin BA. (2011) 'Dairy, dairy, quite contrary: Further evidence to support a role for calcium in counteracting the cholesterol-raising effect of SFA in dairy foods'. British Journal of Nutrition, 105 (12), pp. 1713-1714.
    doi: 10.1017/S0007114510005593
  • Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A, Athyros V, de Graaf J, März W, Parhofer KG, Rini GB, Spinas GA, Tomkin GH, Tselepis AD, Wierzbicki AS, Winkler K, Florentin M, Liberopoulos E. (2011) '"European panel on low density lipoprotein (LDL) subclasses": A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses'. Current Vascular Pharmacology, 9 (5), pp. 533-571.
  • Mikhailidis DP, Elisaf M, Rizzo M, Berneis K, Griffin B, Zambon A, Athyros V, de Graaf J, März W, Parhofer KG, Rini GB, Spinas GA, Tomkin GH, Tselepis AD, Wierzbicki AS, Winkler K, Florentin M, Liberopoulos E. (2011) 'European panel on low density lipoprotein (LDL) subclasses: A statement on the pathophysiology, atherogenicity and clinical significance of LDL subclasses: Executive summary'. Current Vascular Pharmacology, 9 (5), pp. 531-532.
  • Walker CG, Loos RJF, Olson AD, Frost GS, Griffin BA, Lovegrove JA, Sanders TAB, Jebb SA, RISCK Study Grp . (2011) 'Genetic predisposition influences plasma lipids of participants on habitual diet, but not the response to reductions in dietary intake of saturated fatty acids'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, 215 (2), pp. 421-427.
    doi: 10.1016/j.atherosclerosis.2010.12.039
  • Jebb SA, Lovegrove JA, Griffin BA, Frost GS, Moore CS, Chatfield MD, Bluck LJ, Williams CM, Sanders TAB, RISCK Study Grp . (2010) 'Effect of changing the amount and type of fat and carbohydrate on insulin sensitivity and cardiovascular risk: the RISCK (Reading, Imperial, Surrey, Cambridge, and Kings) trial'. AMER SOC CLINICAL NUTRITION AM J CLIN NUTR, 92 (4), pp. 748-758.
    doi: 10.3945/ajcn.2009.29096
  • Isherwood C, Wong M, Jones WS, Davies IG, Griffin BA. (2010) 'LACK OF EFFECT OF COLD WATER PRAWNS ON PLASMA CHOLESTEROL AND LIPOPROTEINS IN NORMO-LIPIDAEMIC MEN'. C M B ASSOC CELL MOL BIOL, 56 (1), pp. 52-58.
    doi: 10.1170/T879
  • Hampton SM, Isherwood C, Kirkpatrick VJE, Lynne-Smith AC, Griffin BA. (2010) 'The influence of alcohol consumed with a meal on endothelial function in healthy individuals'. WILEY-BLACKWELL PUBLISHING, INC J HUM NUTR DIET, 23 (2), pp. 120-125.
    doi: 10.1111/j.1365-277X.2009.01021.x
  • Moore C, Gitau R, Goff L, Lewis FJ, Griffin MD, Chatfield MD, Jebb SA, Frost GS, Sanders TAB, Griffin BA, Lovegrove JA, RISCK Study Grp . (2009) 'Successful Manipulation of the Quality and Quantity of Fat and Carbohydrate Consumed by Free-Living Individuals Using a Food Exchange Model'. AMER SOC NUTRITIONAL SCIENCE J NUTR, 139 (8), pp. 1534-1540.
    doi: 10.3945/jn.108.103374
  • Morgan LM, Griffin BA, Millward DJ, Delooy A, Fox KR, Baic S, Bonham MP, Wallace JMW, MacDonald I, Taylor MA, Truby H. (2009) 'Comparison of the effects of four commercially available weight-loss programmes on lipid-based cardiovascular risk factors'. CAMBRIDGE UNIV PRESS PUBLIC HEALTH NUTR, 12 (6), pp. 799-807.
    doi: 10.1017/S1368980008003236
  • Griffin B, Gray J. (2009) 'The nutritional properties of eggs'. Food Science and Technology, 23 (4), pp. 14-16.
  • Mason P, Porter SC, Berry SE, Stillman P, Steele C, Kirby A, Griffin BA, Minihane AM. (2009) 'Saturated fatty acid consumption: Outlining the scale of the problem and assessing the solutions'. Nutrition Bulletin, 34 (1), pp. 74-84.
  • Rasmussen JG, Eschen RB, Aardestrup IV, Dethlefsen C, Griffin BA, Schmidt EB. (2009) 'Flow-mediated vasodilatation: Variation and interrelationships with plasma lipids and lipoproteins'. Scandinavian Journal of Clinical and Laboratory Investigation, 69 (1), pp. 156-160.
  • Gray J, Griffin B. (2009) 'Eggs and dietary cholesterol - dispelling the myth'. Nutrition Bulletin, 34 (1), pp. 66-70.
  • Griffin BA. (2009) 'Lipid metabolism'. Surgery, 27 (1), pp. 1-5.
  • Lloyd DAJ, Paynton SE, Bassett P, Mateos AR, Lovegrove JA, Gabe SM, Griffin BA. (2008) 'Assessment of long chain n-3 polyunsaturated fatty acid status and clinical outcome in adults receiving home parenteral nutrition'. CHURCHILL LIVINGSTONE CLIN NUTR, 27 (6), pp. 822-831.
    doi: 10.1016/j.clnu.2008.06.003
  • Ferns G, Keti V, Griffin B. (2008) 'Investigation and management of hypertriglyceridaemia.'. J Clin Pathol, England: 61 (11), pp. 1174-1183.
    doi: 10.1136/jcp.2008.055756
  • Harman NL, Leeds AR, Griffin BA. (2008) 'Increased dietary cholesterol does not increase plasma low density lipoprotein when accompanied by an energy-restricted diet and weight loss'. DR DIETRICH STEINKOPFF VERLAG EUR J NUTR, 47 (6), pp. 287-293.
    doi: 10.1007/s00394-008-0730-y
  • Griffin BA. (2008) 'How relevant is the ratio of dietary n-6 to n-3 polyunsaturated fatty acids to cardiovascular disease risk? Evidence from the OPTILIP study'. LIPPINCOTT WILLIAMS & WILKINS CURR OPIN LIPIDOL, 19 (1), pp. 57-62.
    doi: 10.1097/MOL.0b013e3282f2e2a8
  • Khodadadi I, Griffin B, Thumser A. (2008) 'Differential effects of long-chain fatty acids and clofibrate on gene expression profiles in cardiomyocytes.'. Arch Iran Med, Iran: 11 (1), pp. 42-49.
    Full text is available at: http://epubs.surrey.ac.uk/1954/
  • Stanley JC, El Som RL, Calder PC, Griffin BA, Harris WS, Jebb SA, Lovegrove JA, Moore CS, Riemersma RA, Sanders TAB. (2007) 'UK Food Standards Agency Workshop Report: the effects of the dietary n-6 : n-3 fatty acid ratio on cardiovascular health'. CAMBRIDGE UNIV PRESS BRIT J NUTR, 98 (6), pp. 1305-1310.
    doi: 10.1017/S000711450784284X
    Full text is available at: http://epubs.surrey.ac.uk/2612/
  • Griffin BA, Paynton SE, Lloyd DAJ, Gabe SM, Mateos AR, Lovegrove JA. (2007) 'Plasma long-chain n-3 PUFA status in patients receiving long-term home parenteral nutrition'. CAMBRIDGE UNIV PRESS P NUTR SOC, 66, pp. 92A-92A.
  • Paschos GK, Zampelas A, Panagiotakos DB, Katsiougiannis S, Griffin BA, Votteas V, Skopouli FN. (2007) 'Effects of flaxseed oil supplementation on plasma adiponectin levels in dyslipidemic men'. European Journal of Nutrition, 46 (6), pp. 315-320.
  • Moore C, Gitau R, Frost GS, Griffin BA, Jebb SA, Sanders TA, Lovegrove JA. (2007) 'Strategy to alter the amount and composition of dietary carbohydrate and fat in free-living individuals participating in the RISCK trial'. CAMBRIDGE UNIV PRESS P NUTR SOC, 66, pp. 86A-86A.
  • Harman NL, Pourfarzam M, Neely RDG, Griffin BA. (2007) 'Plasma sterols as markers of cholesterol absorption and synthesis: inter-relationships with plasma lipids and apoE genotype'. CAMBRIDGE UNIV PRESS P NUTR SOC, 66, pp. 35A-35A.
  • Stanley JC, Elsom RL, Calder PC, Griffin BA, Harris WS, Jebb SA, Lovegrove JA, Moore CS, Riemersma RA, Sanders TAB. (2007) 'UK Food Standards Agency Workshop Report: The effects of the dietary'. British Journal of Nutrition, 98 (6), pp. 1305-1310.
  • Griffin MD, Sanders TA, Davies IG, Morgan LM, Millward DJ, Lewis F, Slaughter S, Cooper JA, Miller GJ, Griffin BA. (2006) 'Effects of altering the ratio of dietary n-6 to n-3 fatty acids on insulin sensitivity, lipoprotein size, and postprandial lipemia in men and postmenopausal women aged 45-70 y: the OPTILIP Study.'. Am J Clin Nutr, United States: 84 (6), pp. 1290-1298.
  • Sanders TAB, Lewis F, Slaughter S, Griffin BA, Griffin M, Davies I, Millward DJ, Cooper JA, Miller GJ. (2006) 'Effect of varying the ratio of n-6 to n-3 fatty acids by increasing the dietary intake of alpha-linolenic acid, eicosapentaenoic and docosahexaenoic acid, or both on fibrinogen and clotting factors VII and XII in persons aged 45-70 y: the OPTILIP Study'. AMER SOC CLINICAL NUTRITION AM J CLIN NUTR, 84 (3), pp. 513-522.
  • Sanders TAB, Gleason K, Griffin B, Miller GJ. (2006) 'Influence of an algal triacylglycerol containing docosahexaenoic acid (22:6n-3) and docosapentaenoic acid (22:5n-6) on cardiovascular risk factors in healthy men and women'. British Journal of Nutrition, 95 (3), pp. 525-531.
  • Griffin MD, Sanders TAB, Davies IG, Lewis F, Slaughter S, Millward DJ, Griffin BA. (2006) 'The effects of altering the dietary n-6 : n-3 fatty acids ratio on insulin sensitivity, lipoprotein size and postprandial lipaemia in older UK men and women. The OPTILIP study.'. CAMBRIDGE UNIV PRESS P NUTR SOC, 65, pp. 88A-88A.
  • Lee A, Griffin B. (2006) 'Dietary cholesterol, eggs and coronary heart disease risk in perspective'. Nutrition Bulletin, 31 (1), pp. 21-27.

Conference papers

  • Hakim O, Shojaee-Moradie F, Hart K, Berry J, Eastell R, Gossiel F, Hannon R, Umpleby M, Griffin B, Lanham-New S. (2011) 'Evidence of a link between poor bone health, low vitamin D status and CVD risk in caucasian and asian women'. ELSEVIER SCIENCE INC BONE, Athens, GREECE: 3rd Joint Meeting of the European-Calcified-Tissue-Society/International-Bone-and-Mineral-Society 48, pp. S197-S198.
    doi: 10.1016/j.bone.2011.03.698
  • Hakim O, Lanham-New S, Shojaee-Moradie F, Morgan L, Umpleby A, Griffin B, Berry J, Eastell R, Gossiel F, Hannon R, Hart K. (2010) 'POORER LIPID PROFILE ARE ASSOCIATED WITH INCREASED BONE RESORPTION AND PARATHYROID HORMONE: PRELIMINARY RESULTS OF THE D-FINES STUDY'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Liverpool, ENGLAND: Osteoporosis Conference 21, pp. S506-S507.
  • Hakim O, Hart K, Morgan L, Griffin B, Lanham-New S, Shojaee-Moradie F, Umpleby A, Berry J. (2010) '(PREMIER POSTER-AWARD CANDIDATE) EVIDENCE OF A LINK BETWEEN OSTEOPOROSIS RISK AND CVD IN CAUCASIAN BUT NOT ASIAN WOMEN: RESULTS OF THE D-FINES STUDY'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Liverpool, ENGLAND: Osteoporosis Conference 21, pp. S466-S467.
  • Hakim OA, Darling A, Starkey S, Wong M, Shojaee-Moradie F, Hart K, Morgan L, Berry J, Umpleby A, Griffin B, Lanham-New S. (2010) 'POOR BONE HEALTH AND INCREASED CARDIOVASCULAR DISEASE RISK: EVIDENCE OF A LINK IN THE D-FINES STUDY POPULATION'. SPRINGER LONDON LTD OSTEOPOROSIS INTERNATIONAL, Florence, ITALY: IOF World Congress on Osteoporosis/10th European Congress on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis 21, pp. 96-97.
  • Harman NL, Leeds AR, Griffin BA. (2009) 'INCREASED DIETARY CHOLESTEROL DOES NOT INCREASE PLASMA LOW DENSITY LIPOPROTEIN WHEN ACCOMPANIED BY WEIGHT LOSS'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Liverpool Hope Univ, Liverpool, ENGLAND: 23rd Annual Medical and Scientific Meeting of HEART-UK 207 (1), pp. 307-307.
    doi: 10.1016/j.atherosclerosis.2009.07.006
  • Harman NL, Davies IG, Griffin BA. (2007) 'Separation of the principal HDL subclasses by iodixanol gradient ultracentrifugation'. ELSEVIER IRELAND LTD ATHEROSCLEROSIS, Heriot Watt Univ, Edinburgh, SCOTLAND: 21st Annual Medical and Scientific Meeting of HEART-UK 194 (1), pp. 283-284.
    doi: 10.1016/j.atherosclerosis.2007.04.038

Book chapters

  • Griffin BA. (2011) 'Eggs, dietary cholesterol and disease: facts and folklore'. in Bain M, Nys Y, Immerseel FV (eds.) Improving the Safety and Quality of Eggs and Egg Products: Volume 2 Woodhead Pub Ltd 2 Article number 12 , pp. 235-253.
  • Griffin BA. (2009) 'Nutrition and Metabolism of Lipids'. in Gibney MJ (ed.) Introduction to human nutrition 2nd Edition. Blackwell Pub , pp. 86-121.

Teaching

Teaching and Administration within the Faculty and University 

I teach and examine on five undergraduate modules associated with BSc Degree programmes in Nutrition & Dietetics, Nutrition, Nutrition & Food Science and Biochemistry, and three MSc programmes.

  • BSc Degree programmes in Nutrition, Nutrition & Dietetics; Nutrition & Food Science, lecture topics include the Regulation & disorders of energy and lipid metabolism; Biomedical sciences; Macronutrients (dietary fats), Nutrition population groups (cardiovascular disease).

  • MSc Degree programmes in Clinical Biochemistry (lipids & lipoproteins biochemistry, molecular basis of hyperlipidaemia); Nutritional Medicine (Lipids & essential fatty acids); Toxicology (medical - oxidised lipids and trans fatty acids).

Admissions Tutor for MSc in Clinical biochemistry

Departmental Duties

Supervise MSc and PhD research programmes, 

Chairman for the Exam Board in Nutritional Medicine 2006 to date

Degree programme review panel member for BSc Undergraduate Framework for Lifelong Learning in Health and Social Care Practice, EIHMS, University of Surrey (2007)

Member of the Faculty’s Research Advisory Board, FHMS, University of Surrey

Affiliations

  • Biochemical Society (1985-88). 
  • British Hyperlipidaemia Association (1990-02)
  • H.E.A.R.T. UK (2002 - to date) 
  • The Nutrition Society (1994 - to date). 
  • British Atherosclerosis Society (1997 - to date). 
  • The Royal Society of Medicine’s Forum on Lipids in Clinical Medicine (99-06) 
  • Scottsh Heart and Arterial disease Risk Prevention Group (99-03) 
  • Registered Public Health Nutritionist (RPHNutr,1999- to date)

Editorial board membership Assistant Editor for the British Journal of Nutrition (2007-to date)

Editorial Board member - Atherosclerosis(2003-to date)

Committees

British Hyperlipidaemia Association (BHA) Committee member (1999-02)

Chairman for ILSI Europe’s Functional Foods Task Force meetings in Lisbon, Portugal (2003) and Bordeaux, France (2004)

Deputy Director of Supra-regional Assay Service (SAS) in Cardiovascular

Risk Assessment for the NHS Trust University of Surrey & RSCH (2003-to date)

Glucose Molecule : Anna Tanczos

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