Professor Margaret Rayman
Professor of Nutritional Medicine
Qualifications: BSc, DPhil (Oxon), RPHNutr
Email: m.rayman@surrey.ac.uk
Phone: Work: 01483 68 6447
Room no: 18 AY 03
Office hours
By Appointment
Further information
Biography
Professor Margaret Rayman has a doctorate in Inorganic Biochemistry from Somerville College, Oxford and has held post-doctoral fellowships at the Institute of Cancer Research and Imperial College. She is now Professor of Nutritional Medicine at the University of Surrey where she directs the highly respected MSc Programme in Nutritional Medicine.
Her research centres on the importance of trace elements to human health with particular emphasis on selenium in prostate cancer and the pregnancy disease pre-eclampsia. She is also investigating the relationship between selenium, iodine and thyroid function. She has published widely, including a paper in Cancer Research that showed a link between prostate cancer risk and selenoprotein genotype.
She has been a judge for the BBC Radio 4 Food and Farming Awards and sits as a magistrate in Surrey.
Research Interests
Since returning from a lengthy career gap (20-years out of research), my work, which has been full-time for the last nine years has focused on trace elements of importance to health, most notably selenium but also iron and latterly, iodine (see selected publications below).
- I am currently running a trial of low-dose selenium in pregnancy to see if the risk of the pregnancy disease pre-eclampsia can be reduced.
- One of my major interests is the importance of selenium in prostate cancer risk and progression (see information below on my book on diet and prostate cancer, funded by the Prostate Cancer Research Foundation).
- I am also looking at the interaction between iodine, selenium and thyroid function in pregnancy.
Research Collaborations
I currently collaborate with academics at 17 other universities and two research institutes.
Publications
Journal articles
- . (2011) 'Iodine concentration of organic and conventional milk: implications for iodine intake.'. Br J Nutr, , pp. 1-6.
- . (2011) 'Effect of Supplementation With High-Selenium Yeast on Plasma Lipids A Randomized Trial'. AMER COLL PHYSICIANS ANN INTERN MED, 154 (10), pp. 656-W240.
- . (2011) 'Selenium status and blood lipids: the cardiovascular risk in young finns study.'. J Intern Med,
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(2011) 'Maternal selenium status during early gestation and risk for preterm birth'. CMA-CANADIAN MEDICAL ASSOC CAN MED ASSOC J, 183 (5), pp. 549-555.doi: 10.1503/cmaj.101095
- . (2011) 'Selenium status and blood lipids: The cardiovascular risk in young finns study'. Journal of Internal Medicine, 270 (5), pp. 469-477.
- . (2011) 'Maternal selenium status during early gestation and risk for Preterm Birth'. Obstetrical and Gynecological Survey, 66 (7), pp. 400-401.
- . (2011) 'Iodine deficiency in UK schoolgirls'. The Lancet, 378 (9803), pp. 1623-1623.
- . (2010) 'Selenium status and cardiometabolic health: State of the evidence'. ELSEVIER SCI LTD NUTR METAB CARDIOVAS, 20 (10), pp. 754-760.
- . (2010) 'Effect of supplementation with selenium on postpartum depression: a randomized double-blind placebo-controlled trial'. INFORMA HEALTHCARE J MATERN-FETAL NEO M, 24 (1), pp. 104-108.
- . (2010) 'SELENIUM SUPPLEMENTATION AND THE INCIDENCE OF PREECLAMPSIA IN PREGNANT IRANIAN WOMEN: A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED PILOT TRIAL'. ELSEVIER TAIWAN TAIWAN J OBSTET GYNE, 49 (2), pp. 181-187.
- . (2010) 'The Effect of Maternal Selenium Supplementation on Pregnancy Outcome and the Level of Oxidative Stress in Neonates'. IRANIAN RES CRESCENT SOC IRAN RED CRESCENT ME, 12 (3), pp. 254-259.
- . (2010) 'Plasma selenium and risk of dysglycemia in an elderly French population: results from the prospective Epidemiology of Vascular Ageing Study'. BIOMED CENTRAL LTD NUTR METAB, 7 Article number 21
- . (2010) 'Selenium supplementation and premature (pre-labour) rupture of membranes: A randomised double-blind placebo-controlled trial'. INFORMA HEALTHCARE J OBSTET GYNAECOL, 30 (1), pp. 30-34.
- . (2010) 'Higher Selenium Status is Associated with Adverse Blood Lipid Profile in British Adults'. AMER SOC NUTRITIONAL SCIENCE J NUTR, 140 (1), pp. 81-87.
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(2010) 'Prooxidant-antioxidant balance in pregnancy: a randomized double-blind placebo-controlled trial of selenium supplementation'. WALTER DE GRUYTER & CO J PERINAT MED, 38 (5), pp. 473-478.doi: 10.1515/JPM.2010.068
- . (2010) 'Selenium status and cardiometabolic health: State of the evidence'. Nutrition, Metabolism and Cardiovascular Diseases, 20 (10), pp. 754-760.
- . (2009) 'Selenoproteins and human health: Insights from epidemiological data'. ELSEVIER SCIENCE BV BBA-GEN SUBJECTS, 1790 (11), pp. 1533-1540.
- . (2009) 'Selenium and Vitamin E Supplementation for Cancer Prevention'. AMER MEDICAL ASSOC JAMA-J AM MED ASSOC, 301 (18), pp. 1876-1876.
- . (2009) 'Plasma selenium concentration and prostate cancer risk'. AMER SOC CLINICAL NUTRITION AM J CLIN NUTR, 89 (4), pp. 1276-1277.
- . (2008) 'Interaction between Single Nucleotide Polymorphisms in Selenoprotein P and Mitochondrial Superoxide Dismutase Determines Prostate Cancer Risk'. AMER ASSOC CANCER RESEARCH CANCER RES, 68 (24), pp. 10171-10177.
- . (2008) 'Effect of selenium status and supplementation with high-selenium yeast on plasma homocysteine and B vitamin concentrations in the UK elderly'. WILEY-V C H VERLAG GMBH MOL NUTR FOOD RES, 52 (11), pp. 1324-1333.
- . (2008) 'Food-chain selenium and human health: emphasis on intake'. CAMBRIDGE UNIV PRESS BRIT J NUTR, 100 (2), pp. 254-268.
- . (2008) 'Food-chain selenium and human health: spotlight on speciation'. CAMBRIDGE UNIV PRESS BRIT J NUTR, 100 (2), pp. 238-253.
- . (2008) 'Dietary manipulation on in musculoskeletal conditions'. BAILLIERE TINDALL BEST PRACT RES CL RH, 22 (3), pp. 535-561.
- . (2008) 'A survey to estimate total nutrient intake at conception - Dietary and supplementary'. Journal of Nutritional and Environmental Medicine, 17 (1), pp. 12-43.
- . (2008) 'Survey of total folate intake at conception and assessment of impact of fortification'. Journal of Nutritional and Environmental Medicine, 17 (1), pp. 44-55.
- . (2007) 'Randomised, double blind, placebo-controlled trial of selenium supplementation in adult asthma'. B M J PUBLISHING GROUP THORAX, 62 (6), pp. 483-490.
- . (2007) 'Selenium status influences the effect of folate, vitamin B12 and pyridoxal 5 '-phosphate on homocysteine concentrations'. CAMBRIDGE UNIV PRESS P NUTR SOC, 66, pp. 36A-36A.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 87-92.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 138-142.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 167-172.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 149-153.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 36-45.
- . (2007) 'Final discussion'. Novartis Foundation Symposium, 282, pp. 212-218.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 69-76.
- . (2007) 'Bioavailability and speciation of selenium from selenium-enriched mushrooms'. CAMBRIDGE UNIV PRESS P NUTR SOC, 66, pp. 55A-55A.
- . (2007) 'Discussion'. Novartis Foundation Symposium, 282, pp. 117-122.
- . (2006) 'Impact of selenium on mood and quality of life: a randomized, controlled trial.'. Biol Psychiatry, United States: 59 (2), pp. 147-154.
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(2006) 'Simultaneous identification of selenium-containing glutathione species in selenised yeast by on-line HPLC with ICP-MS and electrospray ionisation quadrupole time of flight (QTOF)-MS/MS'. ROYAL SOC CHEMISTRY J ANAL ATOM SPECTROM, 21 (11), pp. 1256-1263.doi: 10.1039/b601867j
- . (2006) 'Selenium on the menu'. Biologist, 53 (5), pp. 236-241.
- . (2006) 'Do functional selenoprotein SNPs predict the risk of prostate cancer?'. CAMBRIDGE UNIV PRESS P NUTR SOC, 65, pp. 100A-100A.
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(2005) 'Selenium in cancer prevention: a review of the evidence and mechanism of action'. CABI PUBLISHING P NUTR SOC, 64 (4), pp. 527-542.doi: 10.1079/PNS2005467Full text is available at: http://epubs.surrey.ac.uk/2596/
- . (2005) 'Nutrient intake is unrelated to nutrient status in patients with chronic fatigue syndrome'. Journal of Nutritional and Environmental Medicine, 15 (4), pp. 177-189.
- . (2005) 'Selenium-enriched yeast as a nutritional supplement: bioavailability, toxicology, efficacy and new identification of an anti-cancer component'. CAMBRIDGE UNIV PRESS P NUTR SOC, 64, pp. 91A-91A.
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(2004) 'The use of high-selenium yeast to raise selenium status: how does it measure up?'. C A B I PUBLISHING BRIT J NUTR, 92 (4), pp. 557-573.doi: 10.1079/BJN20041251
- . (2004) 'Low selenium is associated with the occurrence of preeclampsia in women from the United Kingdom - Reply'. MOSBY-ELSEVIER AM J OBSTET GYNECOL, 191 (2), pp. 676-677.
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(2004) 'Selenium speciation analysis of selenium-enriched supplements by HPLC with ultrasonic nebulisation ICP-MS and electrospray MS/MS detection'. ROYAL SOC CHEMISTRY J ANAL ATOM SPECTROM, 19 (12), pp. 1529-1538.doi: 10.1039/b411270a
- . (2004) 'Speciation and bioavailability of selenium in yeast-based intervention agents used in cancer chemoprevention studies'. AOAC INTERNATIONAL J AOAC INT, 87 (1), pp. 225-232.
- . (2004) 'Low selenium is associated with the occurrence of preeclampsia in women from the United Kingdom [2] (multiple letters)'. American Journal of Obstetrics and Gynecology, 191 (2), pp. 676-677.
- . (2003) 'Low selenium status is associated with the occurrence of the pregnancy disease preeclampsia in women from the United Kingdom'. MOSBY, INC AM J OBSTET GYNECOL, 189 (5), pp. 1343-1349.
- . (2002) 'Se brought to earth'. ROYAL SOC CHEMISTRY CHEM BRIT, 38 (10), pp. 28-31.
- . (2002) 'Abnormal iron parameters in the pregnancy syndrome preeclampsia'. MOSBY, INC AM J OBSTET GYNECOL, 187 (2), pp. 412-418.
- . (2000) 'The importance of selenium to human health'. LANCET LTD LANCET, 356 (9225), pp. 233-241.
- . (1997) 'Enzymatic digestion for the determination of trace elements in blood serum by inductively coupled plasma mass spectrometry'. ROYAL SOC CHEMISTRY J ANAL ATOM SPECTROM, 12 (4), pp. 429-433.
- . (1997) 'Dietary selenium: Time to act - Low bioavailability in Britain and Europe could be contributing to cancers, cardiovascular disease, and subfertility'. BRITISH MED JOURNAL PUBL GROUP BRIT MED J, 314 (7078), pp. 387-388.
- . (1997) 'Dietary selenium: Time to act'. British Medical Journal, 314 (7078), pp. 387-388.
- . (1996) 'Comparison of selenium levels in pre-eclamptic and normal pregnancies'. HUMANA PRESS INC BIOL TRACE ELEM RES, 55 (1-2), pp. 9-20.
- . (1996) 'Determination of selenium in blood serum by hydride generation inductively coupled plasma mass spectrometry'. ROYAL SOC CHEMISTRY J ANAL ATOM SPECTROM, 11 (1), pp. 61-68.
- . (1975) 'OXIDATION OF N-NITROSOPIPERIDINE IN UDENFRIEND MODEL SYSTEM AND ITS METABOLISM BY RAT-LIVER MICROSOMES'. PERGAMON-ELSEVIER SCIENCE LTD BIOCHEM PHARMACOL, 24 (5), pp. 621-626.
- . (1973) 'POTENTIAL ALKYLATING-AGENTS FROM OXIDATION OF CARCINOGENIC CYCLIC N-NITROSAMINES'. CHURCHILL LIVINGSTONE BRIT J CANCER, 28 (1), pp. 84-84.
- . (1973) 'STRUCTURE AND ACTIVITY IN CHEMICAL CARCINOGENESIS - COMPARISON OF REACTIONS OF 7-BROMOMETHYLBENZ[A]ANTHRACENE AND 7-BROMOMETHYL-12-METHYLBENZ[A]ANTHRACENE WITH MOUSE SKIN DEOXYRIBONUCLEIC ACID IN-VIVO'. AMER CHEMICAL SOC BIOCHEMISTRY-US, 12 (8), pp. 1538-1542.
- . (1973) 'STUDIES OF MECHANISM OF TUMOR INITIATION'. CHURCHILL LIVINGSTONE BRIT J CANCER, 28 (1), pp. 85-85.
- . (1973) 'STRUCTURE AND ACTIVITY IN CHEMICAL CARCINOGENESIS - COMPARISON OF REACTIONS OF 7-BROMOMETHYLBENZ[ALPHA]ANTHRACENE AND 7-BROMOMETHYL-12-METHYLBENZ[ALPHA]ANTHRACENE WITH DEOXYRIBONUCLEIC ACID IN-VITRO'. AMER CHEMICAL SOC BIOCHEMISTRY-US, 12 (6), pp. 1202-1207.
- . (1971) 'REACTION OF 7-BROMOMETHYLBENZ[A]ANTHRACENE WITH NUCLEIC ACIDS, POLYNUCLEOTIDES, AND NUCLEOSIDES'. AMER CHEMICAL SOC BIOCHEMISTRY-US, 10 (23), pp. 4323-&.
- . (1971) 'CHEMISTRY AND BIOLOGICAL-ACTIVITIES OF SOME 7-BROMOMETHYLBENZ[A]ANTHRACENES'. AMER ASSOC CANCER RESEARCH P AM ASSOC CANC RES, 12 (NMAR), pp. 95-&.
Conference papers
- . (2010) 'Factors controlling the distribution of selenium in the environment and their impact on health and nutrition'. CAMBRIDGE UNIV PRESS PROCEEDINGS OF THE NUTRITION SOCIETY, Univ Surrey, Guildford, ENGLAND: Conference on Over-and Undernutrition - Challenges and Approaches 69 (1), pp. 119-132.
- . (2009) 'High-Normal Selenium Status Is Associated with Adverse Lipid Profile in British Adults'. LIPPINCOTT WILLIAMS & WILKINS CIRCULATION, Palm Harbor, FL: Joint Nutrition, Physical Activity and Metabolism Conference/49th Cardiovascular Disease Epidemiology and Prevention 119 (10), pp. E307-E307.
- . (2008) 'Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom'. AMER SOC CLINICAL NUTRITION AMERICAN JOURNAL OF CLINICAL NUTRITION, ROYAL COLL PHYSICIANS, LONDON, ENGLAND: Joint Winter Meeting of the Nutrition-Society / Association-for-the-Study-of-Obesity 87 (2), pp. 370-378.
- . (2007) 'The PRECISE pilot trial: Investigating the relation among selenium, homocysteine, and folate in an elderly UK population'. AMER SOCIETY NUTRITIONAL SCIENCE JOURNAL OF NUTRITION, Washington, DC: International Research Conference on Food, Nutrition, and Cancer 137 (1), pp. 282S-283S.
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(2005) 'Identification of water-soluble gamma-glutamyl-Se-methylselenocysteine in yeast-based selenium supplements by reversed-phase HPLC with ICP-MS and electrospray tandem MS detection'. ROYAL SOC CHEMISTRY JOURNAL OF ANALYTICAL ATOMIC SPECTROMETRY, Budapest, HUNGARY: European Winter Conference on Plasma Spectrochemisty 20 (9), pp. 864-870.doi: 10.1039/b503895b
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(2002) 'The argument for increasing selenium intake'. C A B I PUBLISHING PROCEEDINGS OF THE NUTRITION SOCIETY, UNIV SHEFFIELD, SHEFFIELD, ENGLAND: Meeting of the Nutrition-Society 61 (2), pp. 203-215.doi: 10.1079/PNS2002153
- . (2000) 'Selenium in cancer prevention'. KLUWER ACADEMIC/PLENUM PUBL TRACE ELEMENTS IN MAN AND ANIMALS 10, EVIAN LES BAINS, FRANCE: 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), pp. 575-580.
- . (2000) 'Abnormalities of iron homeostasis in the pregnancy syndrome pre-eclampsia'. KLUWER ACADEMIC/PLENUM PUBL TRACE ELEMENTS IN MAN AND ANIMALS 10, EVIAN LES BAINS, FRANCE: 10th International Symposium on Trace Elements in Man and Animals (TEMA 10), pp. 611-615.
- . (1997) 'Serum elemental concentrations in the pregnancy disease pre-eclampsia'. NATL RESEARCH COUNCIL CANADA TRACE ELEMENTS IN MAN AND ANIMALS - 9, BANFF, CANADA: 9th International Symposium on Trace Elements in Man and Animals (TEMA 9), pp. 71-73.
Books
- . (2009) Healthy Eating: The Prostate Care Cookbook.
- . (2006) Nutrition and arthritis. Wiley-Blackwell
Book chapters
- . (2012) 'Selenium and adverse conditions of human pregnancy'. in Hatfield DL, Berry MJ, Gladyshev VN (eds.) Selenium: Its molecular biology and role in human health 3rd Edition. Springer Article number 42 , pp. 531-546.
- . (2010) 'Selenium'. in Milner JA JA, Romagnolo DF (eds.) Bioactive Compounds and Cancer Springer Article number 19 , pp. 411-448.
Teaching
- BSc degree programmes in Nutrition, Nutrition & Dietetics, Nutrition & Food Science: lecture topics include selenium, iodine and manganese.
- MSc Nutritional Medicine
My major contribution to teaching in the University has been the creation of the very successful Nutritional Medicine post-graduate programme, the first (and still unique) university-level, evidence-based course in the UK designed for the in-service training of doctors and other health professionals in the use of nutritional methods of disease prophylaxis and management.
The Programme, of which I am Director, has now been running for 11 years during which time it has been extremely successful, achieving a high profile and excellent reputation. We draw a considerable number of students from Europe and from countries as far away as China, Canada and South Africa. Currently there are 155 registered part-time students, the majority of whom are practising clinicians, including consultants, and a substantial number of gastroenterologists.
- I organise a number of MSc Nutritional Medicine modules and lecture on topics including selenium, iodine, osteo- and rheumatoid arthritis; diet and prostate cancer; pre-eclampsia.
- You can read the menu for "The Antioxidant and Phytoprotectant Dinner" which forms part of the learning experience on the “Antioxidants and Phytoprotectants” module.
- You can find information on Nutritional Medicine at
http://www.surrey.ac.uk/SBMS/pg_taught_courses/nutrition.html
Departmental Duties
Director, Nutritional Medicine MSc Programme
Admissions Tutor, Nutritional Medicine MSc Programme
Chair, Nutritional Medicine Board of Studies
Affiliations
- Registered Public Health Nutritionist (professional qualification of The Nutrition Society)
- Active member of the Nutrition Society
- Member of Council of the Nutrition Society from 2007
